Journal article
Regulation of Nucleus Accumbens Activity by the Hypothalamic Neuropeptide Melanin-Concentrating Hormone
The Journal of neuroscience, Vol.30(24), pp.8263-8273
06/16/2010
DOI: 10.1523/JNEUROSCI.5858-09.2010
PMID: 20554878
Abstract
The lateral hypothalamus and the nucleus accumbens shell (AcbSh) are brain regions important for food intake. The AcbSh contains high levels of receptor for melanin-concentrating hormone (MCH), a lateral hypothalamic peptide critical for feeding and metabolism. MCH receptor (MCHR1) activation in the AcbSh increases food intake, while AcbSh MCHR1 blockade reduces feeding. Here biochemical and cellular mechanisms of MCH action in the rodent AcbSh are described. A reduction of phosphorylation of GluR1 at serine 845 (pSer
Details
- Title: Subtitle
- Regulation of Nucleus Accumbens Activity by the Hypothalamic Neuropeptide Melanin-Concentrating Hormone
- Creators
- Robert M Sears - Department of Psychiatry, Ribicoff Research Facilities, Yale University School of Medicine, New Haven, Connecticut 06508Rong-Jian Liu - Department of Psychiatry, Ribicoff Research Facilities, Yale University School of Medicine, New Haven, Connecticut 06508Nandakumar S Narayanan - The John B. Pierce Laboratory, New Haven, Connecticut 06519Ruth Sharf - Department of Psychiatry, Ribicoff Research Facilities, Yale University School of Medicine, New Haven, Connecticut 06508Mark F Yeckel - Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut 06520Mark Laubach - Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut 06520George K Aghajanian - Department of Psychiatry, Ribicoff Research Facilities, Yale University School of Medicine, New Haven, Connecticut 06508Ralph J DiLeone - Department of Psychiatry, Ribicoff Research Facilities, Yale University School of Medicine, New Haven, Connecticut 06508
- Resource Type
- Journal article
- Publication Details
- The Journal of neuroscience, Vol.30(24), pp.8263-8273
- Publisher
- Society for Neuroscience
- DOI
- 10.1523/JNEUROSCI.5858-09.2010
- PMID
- 20554878
- ISSN
- 0270-6474
- eISSN
- 1529-2401
- Language
- English
- Date published
- 06/16/2010
- Academic Unit
- Neurology; Iowa Neuroscience Institute
- Record Identifier
- 9984020626502771
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