Journal article
Regulation of Oleoyl‐CoA Synthesis in the Peripheral Nervous System: Demonstration of a Link with Myelin Synthesis
Journal of neurochemistry, Vol.71(4), pp.1719-1726
10/1998
DOI: 10.1046/j.1471-4159.1998.71041719.x
PMID: 9751207
Abstract
: We studied the regulation of oleic acid synthesis in the PNS. During mouse postnatal development, the proportion of 18:1 rises in the sciatic nerve from 17% at 5 days of age to 33% at 25 days. However, this rise does not occur in the dysmyelinating mutant mouse trembler. In normal mouse development, the total stearoyl‐CoA desaturase (SCD) activity measured in sciatic nerve homogenates is high during the first 3 weeks. Yet in trembler nerves, this SCD activity represents only 15% of normal values. Using the RT‐PCR technique, we demonstrate that the SCD2 isoform is predominantly expressed in the PNS. Northern blot analysis showed that the mRNA levels for SCD2 parallel those of other specific myelin proteins in both normal mouse and trembler mutant development. Similar experiments in a rat demyelination‐remyelination model confirmed that SCD2 mRNA levels are regulated in the PNS in a similar manner to myelin‐specific proteins.
Details
- Title: Subtitle
- Regulation of Oleoyl‐CoA Synthesis in the Peripheral Nervous System: Demonstration of a Link with Myelin Synthesis
- Creators
- Bertrand GarbayFrançoise Boiron‐SargueilMichael ShyTaibi ChbihiHuiyuan JiangJohn KamholzClaude Cassagne
- Resource Type
- Journal article
- Publication Details
- Journal of neurochemistry, Vol.71(4), pp.1719-1726
- DOI
- 10.1046/j.1471-4159.1998.71041719.x
- PMID
- 9751207
- NLM abbreviation
- J Neurochem
- ISSN
- 0022-3042
- eISSN
- 1471-4159
- Publisher
- Blackwell Science Ltd; Oxford, UK
- Language
- English
- Date published
- 10/1998
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute
- Record Identifier
- 9984020718902771
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