Journal article
Regulation of Wnt signaling by protocadherins
Seminars in cell & developmental biology, Vol.69, pp.158-171
09/2017
DOI: 10.1016/j.semcdb.2017.07.043
PMCID: PMC5586504
PMID: 28774578
Abstract
The ∼70 protocadherins comprise the largest group within the cadherin superfamily. Their diversity, the complexity of the mechanisms through which their genes are regulated, and their many critical functions in nervous system development have engendered a growing interest in elucidating the intracellular signaling pathways through which they act. Recently, multiple protocadherins across several subfamilies have been implicated as modulators of Wnt signaling pathways, and through this as potential tumor suppressors. Here, we review the extant data on the regulation by protocadherins of Wnt signaling pathways and components, and highlight some key unanswered questions that could shape future research.
Details
- Title: Subtitle
- Regulation of Wnt signaling by protocadherins
- Creators
- Kar Men Mah - Department of Biology, The University of Iowa, Iowa City, IA, USAJoshua A Weiner - Department of Biology, The University of Iowa, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Seminars in cell & developmental biology, Vol.69, pp.158-171
- DOI
- 10.1016/j.semcdb.2017.07.043
- PMID
- 28774578
- PMCID
- PMC5586504
- NLM abbreviation
- Semin Cell Dev Biol
- ISSN
- 1084-9521
- eISSN
- 1096-3634
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 09/2017
- Academic Unit
- Liberal Arts and Science Admin; Psychiatry; Iowa Neuroscience Institute; Biology
- Record Identifier
- 9983997437402771
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