Journal article
Regulation of antigen-specific CD8+ T cell homeostasis by perforin and interferon-γ
Science (American Association for the Advancement of Science), Vol.290(5495), pp.1354-1357
2000
DOI: 10.1126/science.290.5495.1354
PMID: 11082062
Abstract
T cell memory depends on factors that regulate expansion and death of these cells after antigenic stimulation. Mice deficient in perforin and interferon-gamma (IFN-gamma) exhibited increased expansion, altered immunodominance, and decreased death of antigen-specific CD8+ T cells after infection with an attenuated strain of Listeria monocytogenes, which was cleared from these mice. Expansion of CD8+ T cells was controlled by perforin, whereas IFN-gamma regulated immunodominance and the death phase. Thus, perforin and IFN-gamma regulate distinct elements of CD8+ T cell homeostasis independently of their role as antimicrobial effector molecules.
Details
- Title: Subtitle
- Regulation of antigen-specific CD8+ T cell homeostasis by perforin and interferon-γ
- Creators
- Vladimir P BADOVINAC - Department of Microbiology, University of Iowa, Iowa City, IA 52242, United StatesAmy R TVINNEREIM - Department of Microbiology, University of Iowa, Iowa City, IA 52242, United StatesJohn T HARTY - Department of Microbiology, University of Iowa, Iowa City, IA 52242, United States
- Resource Type
- Journal article
- Publication Details
- Science (American Association for the Advancement of Science), Vol.290(5495), pp.1354-1357
- Publisher
- American Association for the Advancement of Science; Washington, DC
- DOI
- 10.1126/science.290.5495.1354
- PMID
- 11082062
- ISSN
- 0036-8075
- eISSN
- 1095-9203
- Language
- English
- Date published
- 2000
- Academic Unit
- Microbiology and Immunology; Pathology
- Record Identifier
- 9984046817102771
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