Journal article
Regulation of basal cellular physiology by the homeostatic unfolded protein response
The Journal of Cell Biology, Vol.189(5), pp.783-794
01/01/2010
DOI: 10.1083/jcb.201003138
PMCID: PMC2878945
PMID: 20513765
Abstract
The extensive membrane network of the endoplasmic reticulum (ER) is physically juxtaposed to and functionally entwined with essentially all other cellular compartments. Therefore, the ER must sense diverse and constantly changing physiological inputs so it can adjust its numerous functions to maintain cellular homeostasis. A growing body of new work suggests that the unfolded protein response (UPR), traditionally charged with signaling protein misfolding stress from the ER, has been co-opted for the maintenance of basal cellular homeostasis. Thus, the UPR can be activated, and its output modulated, by signals far outside the realm of protein misfolding. These findings are revealing that the UPR causally contributes to disease not just by its role in protein folding but also through its broad influence on cellular physiology.
Details
- Title: Subtitle
- Regulation of basal cellular physiology by the homeostatic unfolded protein response
- Creators
- D. Thomas RutkowskiRamanujan S Hegde
- Resource Type
- Journal article
- Publication Details
- The Journal of Cell Biology, Vol.189(5), pp.783-794
- Publisher
- The Rockefeller University Press
- DOI
- 10.1083/jcb.201003138
- PMID
- 20513765
- PMCID
- PMC2878945
- ISSN
- 0021-9525
- eISSN
- 1540-8140
- Grant note
- 3R01DK084058-04S1 / National Institutes of Health (nih_________::NIH)
- Language
- English
- Date published
- 01/01/2010
- Academic Unit
- Anatomy and Cell Biology; Internal Medicine
- Record Identifier
- 9984094354702771
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