Journal article
Regulation of epithelial-mesenchymal transition through SUMOylation of transcription factors
Cancer research (Chicago, Ill.), Vol.75(1), pp.11-15
01/01/2015
DOI: 10.1158/0008-5472.CAN-14-2824
PMCID: PMC4286453
PMID: 25524900
Abstract
Carcinoma cells can transition from an epithelial-to-mesenchymal differentiation state through a process known as epithelial-mesenchymal transition (EMT). The process of EMT is characterized by alterations in the pattern of gene expression and is associated with a loss of cell polarity, an increase in invasiveness, and an increase in cells expressing cancer stem cell (CSC) markers. The reverse process of mesenchymal-to-epithelial transition (MET) can also occur, though the transitions characterizing EMT and MET can be incomplete. A growing number of transcription factors have been identified that influence the EMT/MET processes. Interestingly, SUMOylation regulates the functional activity of many of the transcription factors governing transitions between epithelial and mesenchymal states. In some cases, the transcription factor is a small ubiquitin-like modifier conjugated directly, thus altering its transcriptional activity or cell trafficking. In other cases, SUMOylation alters transcriptional mechanisms through secondary effects. This review explores the role of SUMOylation in controlling transcriptional mechanisms that regulate EMT/MET in cancer. Developing new drugs that specifically target SUMOylation offers a novel therapeutic approach to block tumor growth and metastasis.
Details
- Title: Subtitle
- Regulation of epithelial-mesenchymal transition through SUMOylation of transcription factors
- Creators
- Maria V Bogachek - Department of Surgery, University of Iowa, Iowa City, IowaJames P De Andrade - Department of Surgery, University of Iowa, Iowa City, IowaRonald J Weigel - Department of Surgery, University of Iowa, Iowa City, Iowa. Department of Anatomy and Cell Biology, University of Iowa, Iowa City, Iowa. Department of Biochemistry, University of Iowa, Iowa City, Iowa. ronald-weigel@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Cancer research (Chicago, Ill.), Vol.75(1), pp.11-15
- DOI
- 10.1158/0008-5472.CAN-14-2824
- PMID
- 25524900
- PMCID
- PMC4286453
- NLM abbreviation
- Cancer Res
- ISSN
- 0008-5472
- eISSN
- 1538-7445
- Publisher
- United States
- Grant note
- R01CA109294 / NCI NIH HHS T32 CA148062 / NCI NIH HHS R01 CA109294 / NCI NIH HHS T32CA148062 / NCI NIH HHS
- Language
- English
- Date published
- 01/01/2015
- Academic Unit
- Molecular Physiology and Biophysics; Anatomy and Cell Biology; Surgery; Biochemistry and Molecular Biology
- Record Identifier
- 9984024522202771
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