Journal article
Regulation of exoprotein gene expression in Staphylococcus aureus by agar
Molecular & general genetics, Vol.202(1), pp.58-61
01/1986
DOI: 10.1007/BF00330517
PMID: 3007938
Abstract
Insertion of the erythromycin-resistance transposon Tn551 into the Staphylococcus aureus chromosome at a site which maps between the purB and ilv loci has a pleiotrophic effect on the production of a number of extracellular proteins. Production of alpha, beta and delta hemolysin, toxic shock syndrome toxin (TSST-1) and staphylokinase was depressed about fifty-fold while protein A production was elevated twenty-fold. Hybridization analysis showed that the defect in expression of TSST-1 and alpha hemolysin was at the transcriptional level. Inability of the mutant strain to express either a cloned TSST-1 gene or the chromosomal gene indicates that the transposon has inactivated a trans-active positive control element. This element has been designated agr for accessory gene regulator.
Details
- Title: Subtitle
- Regulation of exoprotein gene expression in Staphylococcus aureus by agar
- Creators
- P RecseiB KreiswirthM O'ReillyP SchlievertA GrussR P Novick
- Resource Type
- Journal article
- Publication Details
- Molecular & general genetics, Vol.202(1), pp.58-61
- Publisher
- Germany
- DOI
- 10.1007/BF00330517
- PMID
- 3007938
- ISSN
- 0026-8925
- eISSN
- 1432-1874
- Language
- English
- Date published
- 01/1986
- Academic Unit
- Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984001113802771
Metrics
18 Record Views