Regulation of immune responses by E3 ubiquitin ligase Cbl-b

Rong Tang; Wallace Y Langdon; Jian Zhang

doi:10.1016/j.cellimm.2018.11.002

Back

Regulation of immune responses by E3 ubiquitin ligase Cbl-b

Journal article

Open access

Peer reviewed

Regulation of immune responses by E3 ubiquitin ligase Cbl-b

Rong Tang, Wallace Y Langdon and Jian Zhang

Cellular immunology, Vol.340, pp.103878-103878

06/2019

DOI: 10.1016/j.cellimm.2018.11.002

PMID: 30442330

Files and links (1)

url

https://research-repository.uwa.edu.au/en/publications/7bfc7cf4-2790-4669-bd3e-f6c076ccd35fView

Open Access

Abstract

•Cbl-b is a member of RING finger family E3 ubiquitin ligases.•By targeting different substrates in innate and adaptive immune cells, Cbl-b acts as a gate keeper in immune system.•Targeting Cbl-b may represent a potential therapeutic strategy for immunerelated disorders. Casitas B lymphoma-b (Cbl-b), a RING finger E3 ubiquitin ligase, has been identified as a critical regulator of adaptive immune responses. Cbl-b is essential for establishing the threshold for T cell activation and regulating peripheral T cell tolerance through various mechanisms. Intriguingly, recent studies indicate that Cbl-b also modulates innate immune responses, and plays a key role in host defense to pathogens and anti-tumor immunity. These studies suggest that targeting Cbl-b may represent a potential therapeutic strategy for the management of human immune-related disorders such as autoimmune diseases, infections, tumors, and allergic airway inflammation. In this review, we summarize the latest developments regarding the roles of Cbl-b in innate and adaptive immunity, and immune-mediated diseases.

Innate and adaptive immune responses

Ubiquitination

Immune-related disorders

T cell tolerance

Cbl-b

Details

Title: Subtitle: Regulation of immune responses by E3 ubiquitin ligase Cbl-b
Creators: Rong Tang - Department of Nephrology, Xiangya Hospital, Central South University, Changsha, Hunan, PR China
Wallace Y Langdon - School of Biological Sciences, University of Western Australia, Perth, Australia
Jian Zhang - Department of Pathology, The University of Iowa, Iowa City, IA, USA
Resource Type: Journal article
Publication Details: Cellular immunology, Vol.340, pp.103878-103878
DOI: 10.1016/j.cellimm.2018.11.002
PMID: 30442330
NLM abbreviation: Cell Immunol
ISSN: 0008-8749
eISSN: 1090-2163
Publisher: Elsevier Inc
Grant note: DOI: 10.13039/100000002, name: National Institutes of Health, award: R01 AI090901, AI121196, AI123253
Language: English
Date published: 06/2019
Academic Unit: Pathology
Record Identifier: 9984046822702771

Metrics

17 Record Views

72 Times Cited - Web of Science