Journal article
Regulation of immunopathogenesis during Plasmodium and Toxoplasma infections: more parallels than distinctions?
Trends in parasitology, Vol.29(12), pp.593-602
12/2013
DOI: 10.1016/j.pt.2013.10.002
PMCID: PMC3883126
PMID: 24184186
Abstract
•Experimental models of toxoplasmosis and malaria reveal parallel pathways of immunoregulation.•Immunopathology is limited by inhibitory receptors, cytokines, and distinct cell subsets.•Rodent models of toxoplasmosis and malaria continue to reveal new insight into immunoregulatory networks.
Toxoplasma and Plasmodium parasites exact a significant toll on public health. Host immunity required for efficient control of infection by these Apicomplexans involves the induction of potent T cell responses, which sometimes results in immunopathological damage. Thus, protective immune responses must be balanced by regulatory networks that limit immunopathology. We review several key cellular and molecular immunoregulatory networks operational during Toxoplasma and Plasmodium infections. Accumulating data show that despite differences in how the immune response controls these parasites, many host immunoregulatory pathways and cellular networks are common to both. Thus, understanding the cellular and molecular circuits that prevent or regulate immunopathological responses against one parasite is likely to inform our understanding of the host response to the other parasite.
Details
- Title: Subtitle
- Regulation of immunopathogenesis during Plasmodium and Toxoplasma infections: more parallels than distinctions?
- Creators
- Noah S Butler - Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USATajie H Harris - Department of Neuroscience, University of Virginia School of Medicine, Charlottesville, VA 22908, USAIra J Blader - Department of Microbiology and Immunology, The University at Buffalo, The State University of New York, Buffalo, NY 14214, USA
- Resource Type
- Journal article
- Publication Details
- Trends in parasitology, Vol.29(12), pp.593-602
- DOI
- 10.1016/j.pt.2013.10.002
- PMID
- 24184186
- PMCID
- PMC3883126
- NLM abbreviation
- Trends Parasitol
- ISSN
- 1471-4922
- eISSN
- 1471-5007
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 12/2013
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984001129802771
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