Journal article
Regulation of ion channels by secreted Klotho: mechanisms and implications
Kidney international, Vol.77(10), pp.855-860
05/02/2010
DOI: 10.1038/ki.2010.73
PMID: 20375979
Abstract
Klotho is an anti-aging protein predominantly expressed in the kidney, parathyroid glands, and choroid plexus of the brain. It is a single-pass transmembrane protein with a large extracellular domain. The extracellular domain of Klotho is cleaved and released into extracellular fluid, including blood, urine, and cerebrospinal fluid. The membrane-bound full-length Klotho and secreted extracellular domain of Klotho have distinct functions. Membrane Klotho interacts with fibroblast growth factor (FGF) receptors to form high-affinity receptors for FGF23. Secreted Klotho functions as a humoral factor that regulates several ion channels and transporters, and other processes, including insulin and insulin-like growth factor signaling. This mini-review focuses on the mechanisms of regulation of cell-surface abundance of ion channels by secreted Klotho and the importance of these effects of Klotho in physiology and pathological conditions.
Details
- Title: Subtitle
- Regulation of ion channels by secreted Klotho: mechanisms and implications
- Creators
- Chou-Long Huang - Department of Medicine, UT Southwestern Medical Center, Dallas, Texas, USA
- Resource Type
- Journal article
- Publication Details
- Kidney international, Vol.77(10), pp.855-860
- Publisher
- Elsevier Inc
- DOI
- 10.1038/ki.2010.73
- PMID
- 20375979
- ISSN
- 0085-2538
- eISSN
- 1523-1755
- Language
- English
- Date published
- 05/02/2010
- Academic Unit
- Nephrology; Internal Medicine
- Record Identifier
- 9984094646602771
Metrics
16 Record Views