Journal article
Regulation of ion channels by secreted Klotho
Advances in experimental medicine and biology, Vol.728, pp.100-106
2012
DOI: 10.1007/978-1-4614-0887-1_7
PMID: 22396165
Abstract
Klotho is an anti-aging protein predominantly expressed in the kidney, parathyroid glands and choroid plexus of the brain. Klotho exists in two forms, a membrane form and a soluble secreted form. Recent studies show that the secreted Klotho possess sialidase activity and regulates several ion channels via the activity. Removal of terminal sialic acids from N-glycan chains of the epithelial Ca(2+) channel TRPV5 and the renal K(+) channel ROMK by secreted Klotho exposes the underlying disaccharide galactose-N-acetylglucosamine, a ligand for galectin-1. Binding to galectin-1 at the extracellular surface prevents internalization and leads to accumulation of the channels on the plasma membrane. Future studies will investigate whether secreted Klotho regulates cell-surface expression of other membrane glycoproteins via the same mechanism.
Details
- Title: Subtitle
- Regulation of ion channels by secreted Klotho
- Creators
- Chou-Long Huang - Southwestern Medical Center
- Resource Type
- Journal article
- Publication Details
- Advances in experimental medicine and biology, Vol.728, pp.100-106
- DOI
- 10.1007/978-1-4614-0887-1_7
- PMID
- 22396165
- eISBN
- 9781461408871; 1461408873; 9781461408864; 1461408865
- ISSN
- 0065-2598
- eISSN
- 2214-8019
- Language
- English
- Date published
- 2012
- Academic Unit
- Nephrology; Internal Medicine
- Record Identifier
- 9984359921102771
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