Journal article
Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8
American journal of physiology: endocrinology and metabolism, Vol.321(4), pp.E493-E508
10/01/2021
DOI: 10.1152/ajpendo.00195.2021
PMCID: PMC8560382
PMID: 34338039
Abstract
Triglyceride-rich lipoproteins deliver fatty acids to tissues for oxidation and for storage. Release of fatty acids from circulating lipoprotein triglycerides is carried out by lipoprotein lipase (LPL), thus LPL serves as a critical gatekeeper of fatty acid uptake into tissues. LPL activity is regulated by a number of extracellular proteins including three members of the angiopoietin-like family of proteins. In this review, we discuss our current understanding of how, where, and when ANGPTL3, ANGPTL4, and ANGPTL8 regulate lipoprotein lipase activity, with a particular emphasis on how these proteins interact with each other to coordinate triglyceride metabolism and fat partitioning.
Details
- Title: Subtitle
- Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8
- Creators
- Kelli L. Sylvers-Davie - University of IowaBrandon S. J. Davies - University of Iowa
- Resource Type
- Journal article
- Publication Details
- American journal of physiology: endocrinology and metabolism, Vol.321(4), pp.E493-E508
- DOI
- 10.1152/ajpendo.00195.2021
- PMID
- 34338039
- PMCID
- PMC8560382
- ISSN
- 0193-1849
- eISSN
- 1522-1555
- Grant note
- DOI: 10.13039/100000050, name: HHS | NIH | National Heart, Lung, and Blood Institute, award: R01HL130146; DOI: 10.13039/100000050, name: HHS | NIH | National Heart, Lung, and Blood Institute, award: R01HL134787
- Language
- English
- Date published
- 10/01/2021
- Academic Unit
- Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology
- Record Identifier
- 9984288722602771
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