Journal article
Regulation of macrophage functions by FABP-mediated inflammatory and metabolic pathways
Biochimica et biophysica acta. Molecular and cell biology of lipids, Vol.1866(8), pp.158964-158964
08/2021
DOI: 10.1016/j.bbalip.2021.158964
PMCID: PMC8169605
PMID: 33984518
Abstract
Macrophages are almost everywhere in the body, where they serve pivotal functions in maintaining tissue homeostasis, remodeling, and immunoregulation. Macrophages are traditionally thought to differentiate from bone marrow-derived hematopoietic stem cells (HSCs). Emerging studies suggest that some tissue macrophages at steady state originate from embryonic precursors in the yolk sac or fetal liver and are maintained in situ by self-renewal, but bone marrow-derived monocytes can give rise to tissue macrophages in pathogenic settings, such as inflammatory injuries and cancer. Macrophages are popularly classified as Th1 cytokine (e.g. IFNγ)-activated M1 macrophages (the classical activation) or Th2 cytokine (e.g. IL-4)-activated M2 macrophages (the alternative activation). However, given the myriad arrays of stimuli macrophages may encounter from local environment, macrophages exhibit notorious heterogeneity in their phenotypes and functions. Determining the underlying metabolic pathways engaged during macrophage activation is critical for understanding macrophage phenotypic and functional adaptivity under different disease settings. Fatty acid binding proteins (FABPs) represent a family of evolutionarily conserved proteins facilitating lipid transport, metabolism and responses inside cells. More specifically, adipose-FABP (A-FABP) and epidermal-FABP (E-FABP) are highly expressed in macrophages and play a central role in integrating metabolic and inflammatory pathways. In this review we highlight how A-FABP and E-FABP are respectively upregulated in different subsets of activated macrophages and provide a unique perspective in defining macrophage phenotypic and functional heterogeneity through FABP-regulated lipid metabolic and inflammatory pathways.
•Macrophages exhibit phenotypic, metabolic and functional heterogeneity.•FABPs, in particularly A-FABP and E-FABP, are expressed in different subsets of macrophages.•A-FABP and E-FABP regulate lipid metabolism by coordinating different FA-mediated pathways in macrophages.•A-FABP and E-FABP may serve as new metabolic/functional markers defining macrophage heterogeneity.
Details
- Title: Subtitle
- Regulation of macrophage functions by FABP-mediated inflammatory and metabolic pathways
- Creators
- Rong Jin - University of LouisvilleJiaqing Hao - University of LouisvilleYanmei Yi - University of LouisvilleEdward Sauter - Division of Cancer Prevention, NIH/NCI, Bethesda, MD, USABing Li - University of Louisville
- Resource Type
- Journal article
- Publication Details
- Biochimica et biophysica acta. Molecular and cell biology of lipids, Vol.1866(8), pp.158964-158964
- Publisher
- Elsevier B.V
- DOI
- 10.1016/j.bbalip.2021.158964
- PMID
- 33984518
- PMCID
- PMC8169605
- ISSN
- 1388-1981
- eISSN
- 1879-2618
- Grant note
- DOI: 10.13039/100000002, name: NIH
- Language
- English
- Date published
- 08/2021
- Academic Unit
- Pathology
- Record Identifier
- 9984204062402771
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