Regulation of native collateral vessel dilation after coronary occlusion in the dog

Kathryn G Lamping; Eric N Bloom; David G Harrison

doi:10.1152/ajpheart.1994.266.2.h769

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Regulation of native collateral vessel dilation after coronary occlusion in the dog

Journal article

Peer reviewed

Regulation of native collateral vessel dilation after coronary occlusion in the dog

Kathryn G Lamping, Eric N Bloom and David G Harrison

The American journal of physiology, Vol.266(2 Pt 2), pp.H769-H778

02/1994

DOI: 10.1152/ajpheart.1994.266.2.h769

PMID: 8141378

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Abstract

The purpose of this study was to examine mechanisms involved in the response of native collaterals to coronary occlusion. In anesthetized dogs native collaterals were identified as vessels coursing between the left anterior descending and left circumflex arteries using fluorescence angiography. After a left anterior descending occlusion in 12 dogs, collaterals < 100 microns in diameter progressively dilated by 21 +/- 4% (n = 12) 1 min after occlusion and by 39 +/- 6% 15 min after occlusion. Collaterals > 100 microns in diameter did not dilate after coronary occlusion. NG-nitro-L-arginine (1 mg/min intracoronary) caused constriction under basal conditions in collaterals < 100 microns but did not prevent the dilation of collaterals after occlusion. In contrast, glibenclamide (10(-5) M), an inhibitor of ATP-sensitive potassium channels, had no effect on baseline diameter of collaterals < 100 microns diameter but completely prevented dilation of collaterals after occlusion. We conclude that collaterals are not maximally dilated immediately after a coronary occlusion but rather progressively dilate for at least 15 min after an occlusion. This dilation of native collaterals after an occlusion is not mediated by release of an endothelium-derived relaxing factor derived from L-arginine but is mediated by activation of ATP-sensitive K+ channels.

Diastole

Potassium Channels - physiology

Male

Microcirculation - anatomy & histology

Nitroprusside - pharmacology

Systole

Microcirculation - drug effects

Arginine - analogs & derivatives

Microcirculation - physiology

Heart Rate - drug effects

Time Factors

Female

Blood Pressure - drug effects

Nitroarginine

Vasodilation - physiology

Muscle, Smooth, Vascular - physiology

Muscle, Smooth, Vascular - drug effects

Acetylcholine - pharmacology

Coronary Vessels - physiology

Fluorescein Angiography - methods

Potassium Channels - drug effects

Animals

Arginine - pharmacology

Dogs

Vasodilation - drug effects

Details

Title: Subtitle: Regulation of native collateral vessel dilation after coronary occlusion in the dog
Creators: Kathryn G Lamping - Department of Internal Medicine, College of Medicine, University of Iowa, Iowa City 52242
Eric N Bloom
David G Harrison
Resource Type: Journal article
Publication Details: The American journal of physiology, Vol.266(2 Pt 2), pp.H769-H778
DOI: 10.1152/ajpheart.1994.266.2.h769
PMID: 8141378
NLM abbreviation: Am J Physiol
ISSN: 0002-9513
eISSN: 2163-5773
Grant note: HL-39050 / NHLBI NIH HHS HL-32295 / NHLBI NIH HHS
Language: English
Date published: 02/1994
Academic Unit: Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
Record Identifier: 9984094728402771

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28 Times Cited - Web of Science