Journal article
Regulation of sodium and body fluid homeostasis during development: implications for the pathogenesis of hypertension
Experientia, Vol.48(4), pp.345-351
04/15/1992
DOI: 10.1007/BF01923428
PMID: 1582493
Abstract
The spontaneously hypertensive rat (SHR) is an important animal model of human essential hypertension. During the first month of life, increased retention of sodium is present in the SHR which appears to be mediated by the renin-angiotensin system. The present review will discuss the role that increased activity of the renin-angiotensin system plays in sodium/body fluid regulation during early development. It is hypothesized that disordered regulation of sodium/body fluid homeostasis during this stage leads to pathological cardiovascular regulation in adulthood. Through an understanding of the relationship between sodium/body fluid balance in the young and cardiovascular function in the adult insights may be gained into both the pathological state of hypertension and the critical role played by early development in shaping homeostatic mechanisms in adulthood.
Details
- Title: Subtitle
- Regulation of sodium and body fluid homeostasis during development: implications for the pathogenesis of hypertension
- Creators
- R F Kirby - Department of Psychology, University of Iowa, Iowa City 52242A K Johnson
- Resource Type
- Journal article
- Publication Details
- Experientia, Vol.48(4), pp.345-351
- DOI
- 10.1007/BF01923428
- PMID
- 1582493
- ISSN
- 0014-4754
- eISSN
- 1420-9071
- Grant note
- HL35600 / NHLBI NIH HHS HL14388 / NHLBI NIH HHS HL33796 / NHLBI NIH HHS
- Language
- English
- Date published
- 04/15/1992
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; University College Courses; Health and Human Physiology
- Record Identifier
- 9984213409702771
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