Regulation of the cellular heat shock response in Caenorhabditis elegans by thermosensory neurons

Veena Prahlad; Tyler Cornelius; Richard I Morimoto

doi:10.1126/science.1156093

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Regulation of the cellular heat shock response in Caenorhabditis elegans by thermosensory neurons

Journal article

Peer reviewed

Regulation of the cellular heat shock response in Caenorhabditis elegans by thermosensory neurons

Veena Prahlad, Tyler Cornelius and Richard I Morimoto

Science (American Association for the Advancement of Science), Vol.320(5877), pp.811-814

05/09/2008

DOI: 10.1126/science.1156093

PMCID: PMC3429343

PMID: 18467592

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Abstract

Temperature pervasively affects all cellular processes. In response to a rapid increase in temperature, all cells undergo a heat shock response, an ancient and highly conserved program of stress-inducible gene expression, to reestablish cellular homeostasis. In isolated cells, the heat shock response is initiated by the presence of misfolded proteins and therefore thought to be cell-autonomous. In contrast, we show that within the metazoan Caenorhabditis elegans, the heat shock response of somatic cells is not cell-autonomous but rather depends on the thermosensory neuron, AFD, which senses ambient temperature and regulates temperature-dependent behavior. We propose a model whereby this loss of cell autonomy serves to integrate behavioral, metabolic, and stress-related responses to establish an organismal response to environmental change.

Transcription Factors - physiology

Caenorhabditis elegans - genetics

Thermosensing - physiology

Genes, Helminth

Pheromones - physiology

Transcription Factors - genetics

Heat-Shock Response - physiology

Neurons, Afferent - physiology

Protein Folding

Heat-Shock Response - genetics

Caenorhabditis elegans - physiology

Heat-Shock Proteins - genetics

Animals

Caenorhabditis elegans - cytology

Caenorhabditis elegans Proteins - physiology

Models, Neurological

Mutation

Heat-Shock Proteins - physiology

Caenorhabditis elegans Proteins - genetics

Details

Title: Subtitle: Regulation of the cellular heat shock response in Caenorhabditis elegans by thermosensory neurons
Creators: Veena Prahlad - Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA
Tyler Cornelius
Richard I Morimoto
Resource Type: Journal article
Publication Details: Science (American Association for the Advancement of Science), Vol.320(5877), pp.811-814
DOI: 10.1126/science.1156093
PMID: 18467592
PMCID: PMC3429343
NLM abbreviation: Science
ISSN: 0036-8075
eISSN: 1095-9203
Publisher: United States
Grant note: R01 AG026647 / NIA NIH HHS R01 AG026647-02 / NIA NIH HHS R01 AG026647-01 / NIA NIH HHS R37 GM038109-21 / NIGMS NIH HHS R37 GM038109-19 / NIGMS NIH HHS R37 GM038109-22 / NIGMS NIH HHS R01 AG026647-04 / NIA NIH HHS R01 GM038109 / NIGMS NIH HHS R37 GM038109 / NIGMS NIH HHS R01 AG026647-03 / NIA NIH HHS R37 GM038109-20 / NIGMS NIH HHS
Language: English
Date published: 05/09/2008
Academic Unit: Iowa Neuroscience Institute; Biology
Record Identifier: 9983992066702771

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