Journal article
Regulation of the cerebral circulation by endothelium
Pharmacology & therapeutics (Oxford), Vol.56(1), pp.1-22
1992
DOI: 10.1016/0163-7258(92)90035-X
PMID: 1297144
Abstract
Endothelium exerts an important influence on cerebral vascular tone through the production and release of a diverse group of vasoactive factors. Relaxing factors produced by endothelium include nitric oxide (or a nitric oxide-containing compound), a hyperpolarizing factor, and prostacyclin. Endothelium-derived contracting factors include cyclooxygenase products of arachidonic acid and endothelins. Severla pathophysiological conditions are associated with increased formation of endothelium-derived contracting factors. Such endothelial dysfunction in the cerebral circulation may shift the balance of vascular tone toward constriction and may potentially contribute to the onset or maintainance of cerebral ischemia and stroke.
Details
- Title: Subtitle
- Regulation of the cerebral circulation by endothelium
- Creators
- Frank M Faraci - Departments of Internal Medicine and Pharmacology, Cardiovascular Center, University of Iowa College of Medicine, Iowa City, IA 52242, U.S.A
- Resource Type
- Journal article
- Publication Details
- Pharmacology & therapeutics (Oxford), Vol.56(1), pp.1-22
- Publisher
- Elsevier Inc
- DOI
- 10.1016/0163-7258(92)90035-X
- PMID
- 1297144
- ISSN
- 0163-7258
- eISSN
- 1879-016X
- Language
- English
- Date published
- 1992
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040476902771
Metrics
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