Regulation of the transcriptome by ER stress: non-canonical mechanisms and physiological consequences

Angela M Arensdorf; Danilo Diedrichs; D. Thomas Rutkowski

doi:10.3389/fgene.2013.00256

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Regulation of the transcriptome by ER stress: non-canonical mechanisms and physiological consequences

Journal article

Open access

Peer reviewed

Regulation of the transcriptome by ER stress: non-canonical mechanisms and physiological consequences

Angela M Arensdorf, Danilo Diedrichs and D. Thomas Rutkowski

Frontiers in genetics, Vol.4, pp.256-256

2013

DOI: 10.3389/fgene.2013.00256

PMCID: PMC3844873

PMID: 24348511

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Abstract

The mammalian unfolded protein response (UPR) is propagated by three ER-resident transmembrane proteins, each of which initiates a signaling cascade that ultimately culminates in production of a transcriptional activator. The UPR was originally characterized as a pathway for upregulating ER chaperones, and a comprehensive body of subsequent work has shown that protein synthesis, folding, oxidation, trafficking, and degradation are all transcriptionally enhanced by the UPR. However, the global reach of the UPR extends to genes involved in diverse physiological processes having seemingly little to do with ER protein folding, and this includes a substantial number of mRNAs that are suppressed by stress rather than stimulated. Through multiple non-canonical mechanisms emanating from each of the UPR pathways, the cell dynamically regulates transcription and mRNA degradation. Here we highlight these mechanisms and their increasingly appreciated impact on physiological processes.

ER stress

Transcription Factors

gene regulatory networks (GRN)

unfolded protein response (UPR)

Endocrinology

mRNA stability

Details

Title: Subtitle: Regulation of the transcriptome by ER stress: non-canonical mechanisms and physiological consequences
Creators: Angela M Arensdorf - Department of Anatomy and Cell Biology, University of Iowa Carver College of Medicine
Danilo Diedrichs - Department of Mathematics and Computer Science, Wheaton College
D. Thomas Rutkowski - Department of Anatomy and Cell Biology, University of Iowa Carver College of Medicine
Resource Type: Journal article
Publication Details: Frontiers in genetics, Vol.4, pp.256-256
DOI: 10.3389/fgene.2013.00256
PMID: 24348511
PMCID: PMC3844873
NLM abbreviation: Front Genet
ISSN: 1664-8021
eISSN: 1664-8021
Publisher: Frontiers Media S.A
Language: English
Date published: 2013
Academic Unit: Anatomy and Cell Biology; Internal Medicine
Record Identifier: 9984094359802771

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