Regulators of G protein Signaling (RGS) proteins (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Mohammed Alqinyah; Christopher Bodle; Josephine Bou Dagher; Bandana Chakravarti; Shreoshi P Choudhuri; Kirk M Druey; Rory A Fisher; Kyle J Gerber; John R Hepler; Shelley B Hooks; Havish S Kantheti; Behirda Karaj; Jae-Kyung Lee; Zili Luo; Kirill Martemyanov; Luke D Mascarenhas; Hoa Phan Thi Nhu; David L Roman; Vincent Shaw; Benita Sjögren; Katherine E Squires; Laurie Sutton; Thomas M Wilkie; Keqiang Xie; Yalda Zolghadri

doi:10.2218/gtopdb/F891/2019.4

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Regulators of G protein Signaling (RGS) proteins (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Journal article

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Regulators of G protein Signaling (RGS) proteins (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Mohammed Alqinyah, Christopher Bodle, Josephine Bou Dagher, Bandana Chakravarti, Shreoshi P Choudhuri, Kirk M Druey, Rory A Fisher, Kyle J Gerber, John R Hepler, Shelley B Hooks, …

IUPHAR/BPS Guide to Pharmacology CITE, Vol.2019(4)

09/16/2019

DOI: 10.2218/gtopdb/F891/2019.4

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Abstract

Regulators of G protein signalling (RGS) proteins display a common RGS domain that interacts with the GTP-bound Gα subunits of heterotrimeric G proteins, enhancing GTP hydrolysis by stabilising the transition state [29, 419, 418], leading to a termination of GPCR signalling. Interactions through protein:protein interactions of many RGS proteins have been identified for targets other than heteromeric G proteins. Sequence analysis of the 20 RGS proteins suggests four families of RGS: RZ, R4, R7 and R12 families. Many of these proteins have been identified to have effects other than through targetting G proteins. Included here is RGS4 for which a number of pharmacological inhibitors have been described.

Details

Title: Subtitle: Regulators of G protein Signaling (RGS) proteins (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
Creators: Mohammed Alqinyah
Christopher Bodle
Josephine Bou Dagher
Bandana Chakravarti
Shreoshi P Choudhuri
Kirk M Druey
Rory A Fisher
Kyle J Gerber
John R Hepler
Shelley B Hooks
Havish S Kantheti
Behirda Karaj
Jae-Kyung Lee
Zili Luo
Kirill Martemyanov
Luke D Mascarenhas
Hoa Phan Thi Nhu
David L Roman
Vincent Shaw
Benita Sjögren
Katherine E Squires
Laurie Sutton
Thomas M Wilkie
Keqiang Xie
Yalda Zolghadri
Resource Type: Journal article
Publication Details: IUPHAR/BPS Guide to Pharmacology CITE, Vol.2019(4)
DOI: 10.2218/gtopdb/F891/2019.4
ISSN: 2633-1020
eISSN: 2633-1020
Language: English
Date published: 09/16/2019
Academic Unit: Pharmacy; Critical Care; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Pharmaceutical Sciences and Experimental Therapeutics; Neuroscience and Pharmacology; Medicinal and Natural Products Chemistry; Internal Medicine
Record Identifier: 9984071735402771

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