Regulators of G protein Signaling (RGS) proteins in GtoPdb v.2021.2

Katelin E Ahlers-Dannen; Mohammed Alqinyah; Christopher Bodle; Josephine Bou Dagher; Bandana Chakravarti; Shreoshi P Choudhuri; Kirk M Druey; Rory A Fisher; Kyle J Gerber; John R Hepler; Shelley B Hooks; Havish S Kantheti; Behirda Karaj; Somayeh Layeghi-Ghalehsoukhteh; Jae-Kyung Lee; Zili Luo; Kirill Martemyanov; Luke D Mascarenhas; Harrison J McNabb; Carolina Montañez-Miranda; Osita W Ogujiofor; Hoa Phan Thi Nhu; David L Roman; Vincent Shaw; Benita Sjögren; Mackenzie M Spicer; Katherine E Squires; Laurie Sutton; Menbere Wendimu; Thomas M Wilkie; Keqiang Xie; Qian Zhang; Yalda Zolghadri

doi:10.2218/gtopdb/F891/2021.2

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Regulators of G protein Signaling (RGS) proteins in GtoPdb v.2021.2

Journal article

Open access

Regulators of G protein Signaling (RGS) proteins in GtoPdb v.2021.2

Katelin E Ahlers-Dannen, Mohammed Alqinyah, Christopher Bodle, Josephine Bou Dagher, Bandana Chakravarti, Shreoshi P Choudhuri, Kirk M Druey, Rory A Fisher, Kyle J Gerber, John R Hepler, …

IUPHAR/BPS Guide to Pharmacology CITE, Vol.2021(2)

06/25/2021

DOI: 10.2218/gtopdb/F891/2021.2

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Abstract

Regulator of G protein Signaling, or RGS, proteins serve an important regulatory role in signaling mediated by G protein-coupled receptors (GPCRs). They all share a common RGS domain that directly interacts with active, GTP-bound Gα subunits of heterotrimeric G proteins. RGS proteins stabilize the transition state for GTP hydrolysis on Gα and thus induce a conformational change in the Gα subunit that accelerates GTP hydrolysis, thereby effectively turning off signaling cascades mediated by GPCRs. This GTPase accelerating protein (GAP) activity is the canonical mechanism of action for RGS proteins, although many also possess additional functions and domains. RGS proteins are divided into four families, R4, R7, R12 and RZ based on sequence homology, domain structure as well as specificity towards Gα subunits. For reviews on RGS proteins and their potential as therapeutic targets, see e.g. [225, 529, 578, 583, 584, 742, 753, 444, 10].

Details

Title: Subtitle: Regulators of G protein Signaling (RGS) proteins in GtoPdb v.2021.2
Creators: Katelin E Ahlers-Dannen
Mohammed Alqinyah - University of Georgia
Christopher Bodle - University of Iowa
Josephine Bou Dagher
Bandana Chakravarti - University of Iowa
Shreoshi P Choudhuri - Southwestern Medical Center
Kirk M Druey - National Institutes of Health
Rory A Fisher - University of Iowa
Kyle J Gerber - Emory University
John R Hepler - Emory University
Shelley B Hooks - University of Georgia
Havish S Kantheti - Southwestern Medical Center
Behirda Karaj - Michigan State University
Somayeh Layeghi-Ghalehsoukhteh
Jae-Kyung Lee
Zili Luo - University of Iowa
Kirill Martemyanov - Scripps Research Institute
Luke D Mascarenhas - Southwestern Medical Center
Harrison J McNabb - Purdue University West Lafayette
Carolina Montañez-Miranda
Osita W Ogujiofor - Southwestern Medical Center
Hoa Phan Thi Nhu
David L Roman - University of Iowa
Vincent Shaw - Michigan State University
Benita Sjögren - Purdue University West Lafayette
Mackenzie M Spicer - University of Iowa
Katherine E Squires - Emory University
Laurie Sutton - Scripps Research Institute
Menbere Wendimu - University of Georgia
Thomas M Wilkie - Southwestern Medical Center
Keqiang Xie - Scripps Research Institute
Qian Zhang - Purdue University West Lafayette
Yalda Zolghadri - Shiraz University
Resource Type: Journal article
Publication Details: IUPHAR/BPS Guide to Pharmacology CITE, Vol.2021(2)
DOI: 10.2218/gtopdb/F891/2021.2
ISSN: 2633-1020
eISSN: 2633-1020
Language: English
Date published: 06/25/2021
Academic Unit: Pharmacy; Critical Care; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Pharmaceutical Sciences and Experimental Therapeutics; Neuroscience and Pharmacology; Medicinal and Natural Products Chemistry; Internal Medicine
Record Identifier: 9984186942402771

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