Regulators of G protein signaling in cardiovascular function during pregnancy

Katherine J Perschbacher; Guorui Deng; Rory A Fisher; Katherine N Gibson-Corley; Mark K Santillan; Justin L Grobe

doi:10.1152/physiolgenomics.00037.2018

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Regulators of G protein signaling in cardiovascular function during pregnancy

Journal article

Open access

Peer reviewed

Regulators of G protein signaling in cardiovascular function during pregnancy

Katherine J Perschbacher, Guorui Deng, Rory A Fisher, Katherine N Gibson-Corley, Mark K Santillan and Justin L Grobe

Physiological Genomics, Vol.50(8), pp.590-604

General Interest

08/01/2018

DOI: 10.1152/physiolgenomics.00037.2018

PMCID: PMC6139632

PMID: 29702036

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Abstract

G protein-coupled receptor signaling mechanisms are implicated in many aspects of cardiovascular control, and dysfunction of such signaling mechanisms is commonly associated with disease states. Investigators have identified a large number of regulator of G protein signaling (RGS) proteins that variously contribute to the modulation of intracellular second-messenger signaling kinetics. These many RGS proteins each interact with a specific set of second-messenger cascades and receptor types and exhibit tissue-specific expression patterns. Increasing evidence supports the contribution of RGS proteins, or their loss, in the pathogenesis of cardiovascular dysfunctions. This review summarizes the current understanding of the functional contributions of RGS proteins, particularly within the B/R4 family, in cardiovascular disorders of pregnancy including gestational hypertension, uterine artery dysfunction, and preeclampsia.

RGS5

RGS2

R4 family

Review

regulator of G protein signaling

pregnancy

Details

Title: Subtitle: Regulators of G protein signaling in cardiovascular function during pregnancy
Creators: Katherine J Perschbacher - University of Iowa
Guorui Deng - University of Iowa
Rory A Fisher - University of Iowa
Katherine N Gibson-Corley - University of Iowa
Mark K Santillan - University of Iowa
Justin L Grobe - University of Iowa
Resource Type: Journal article
Publication Details: Physiological Genomics, Vol.50(8), pp.590-604
Series: General Interest
DOI: 10.1152/physiolgenomics.00037.2018
PMID: 29702036
PMCID: PMC6139632
NLM abbreviation: Physiol Genomics
ISSN: 1094-8341
eISSN: 1531-2267
Publisher: American Physiological Society; Bethesda, MD
Grant note: 15SFRN23730000; 17PRE33660633; 18EIA33890055 / ; ; HL134850; HL084207; AA025919; CA161882; HD091458 / ; ;
Alternative title: RGS PROTEINS IN PREGNANCY
Language: English
Date published: 08/01/2018
Academic Unit: Pathology; Iowa Neuroscience Institute; Obstetrics and Gynecology; Neuroscience and Pharmacology; Internal Medicine; Ophthalmology and Visual Sciences
Record Identifier: 9983931812902771

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