Journal article
Regulatory Actions of Glucocorticoid Hormones: From Organisms to Mechanisms
Advances in experimental medicine and biology, Vol.872, pp.3-31
2015
DOI: 10.1007/978-1-4939-2895-8_1
PMID: 26215988
Abstract
The history of glucocorticoid hormone research is an excellent example of "bedside to bench" investigation. It started with two very insightful clinical observations. Thomas Addison described the syndrome of what came to be known as adrenal hormone insufficiency and Harvey Cushing the syndrome of glucocorticoid hormone excess. These dramatic and life-threatening conditions spawned 150 years of active research that has involved many disciplines; indeed some of the fundamental observations of molecular biology are the result of this work. We have a fundamental knowledge of how glucocorticoids regulate gene transcription, their major effect. The challenge facing current and future investigators is to discern how to use this information to make these powerful therapeutic agents safer and more effective.
Details
- Title: Subtitle
- Regulatory Actions of Glucocorticoid Hormones: From Organisms to Mechanisms
- Creators
- Daryl K Granner - Department of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, 169 Newton Road, 4312 PBDB, Iowa City, IA, 52242, USA, daryl-granner@uiowa.eduJen-Chywan WangKeith R Yamamoto
- Resource Type
- Journal article
- Publication Details
- Advances in experimental medicine and biology, Vol.872, pp.3-31
- Publisher
- United States
- DOI
- 10.1007/978-1-4939-2895-8_1
- PMID
- 26215988
- eISBN
- 1493928953; 9781493928958
- ISSN
- 0065-2598
- eISSN
- 2214-8019
- Language
- English
- Date published
- 2015
- Academic Unit
- Molecular Physiology and Biophysics
- Record Identifier
- 9984020749302771
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