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Reinterpreting Comorbidity: A Model-Based Approach to Understanding and Classifying Psychopathology
Journal article   Peer reviewed

Reinterpreting Comorbidity: A Model-Based Approach to Understanding and Classifying Psychopathology

Robert F Krueger and Kristian E Markon
Annual review of clinical psychology, Vol.2(1), pp.111-133
04/2006
DOI: 10.1146/annurev.clinpsy.2.022305.095213
PMCID: PMC2242354
PMID: 17716066
url
http://doi.org/10.1146/annurev.clinpsy.2.022305.095213View
Open Access

Abstract

Comorbidity has presented a persistent puzzle for psychopathology research. We review recent literature indicating that the puzzle of comorbidity is being solved by research fitting explicit quantitative models to data on comorbidity. We present a meta-analysis of a liability spectrum model of comorbidity, in which specific mental disorders are understood as manifestations of latent liability factors that explain comorbidity by virtue of their impact on multiple disorders. Nosological, structural, etiological, and psychological aspects of this liability spectrum approach to understanding comorbidity are discussed.

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