Journal article
Related peripheral blood stem cell donors experience more severe symptoms and less complete recovery at one year compared to unrelated donors
Haematologica (Roma), Vol.104(4), pp.844-854
04/2019
DOI: 10.3324/haematol.2018.200121
PMCID: PMC6442962
PMID: 30381298
Abstract
Unlike unrelated donor registries, transplant centers lack uniform approaches to related donor assessment and deferral. To test whether related donors are at increased risk for donation-related toxicities, we conducted a prospective observational trial of 11,942 related and unrelated donors aged 18-60 years. Bone marrow (BM) was collected at 37 transplant and 78 National Marrow Donor Program centers, and peripheral blood stem cells (PBSC) were collected at 42 transplant and 87 unrelated donor centers in North America. Possible presence of medical comorbidities was verified prior to donation, and standardized pain and toxicity measures were assessed pre-donation, peri-donation, and one year following. Multivariate analyses showed similar experiences for BM collection in related and unrelated donors; however, related stem cell donors had increased risk of moderate [odds ratios (ORs) 1.42;
<0.001] and severe (OR 8.91;
<0.001) pain and toxicities (OR 1.84;
<0.001) with collection. Related stem cell donors were at increased risk of persistent toxicities (OR 1.56;
=0.021) and non-recovery from pain (OR 1.42;
=0.001) at one year. Related donors with more significant comorbidities were at especially high risk for grade 2-4 pain (OR 3.43;
<0.001) and non-recovery from toxicities (OR 3.71;
<0.001) at one year. Related donors with more significant comorbidities were at especially high risk for grade 2-4 pain (OR 3.43;
<0.001) and non-recovery from toxicities (OR 3.71;
<0.001) at one year. Related donors reporting grade ≥2 pain had significant decreases in Health-Related Quality of Life (HR-QoL) scores at one month and one year post donation (
=0.004). In conclusion, related PBSC donors with comorbidities are at increased risk for pain, toxicity, and non-recovery at one year after donation. Risk profiles described in this study should be used for donor education, planning studies to improve the related donor experience, and decisions regarding donor deferral. Registered at
.
Details
- Title: Subtitle
- Related peripheral blood stem cell donors experience more severe symptoms and less complete recovery at one year compared to unrelated donors
- Creators
- Michael A Pulsipher - Children's Hospital of Los AngelesBrent R Logan - Medical College of WisconsinDeidre M Kiefer - Center for International Blood and Marrow Transplant ResearchPintip Chitphakdithai - Center for International Blood and Marrow Transplant ResearchMarcie L Riches - University of North Carolina at Chapel HillJ Douglas Rizzo - Medical College of WisconsinPaolo Anderlini - The University of Texas MD Anderson Cancer CenterSusan F Leitman - National Institutes of HealthHati Kobusingye - Center for International Blood and Marrow Transplant ResearchRaeAnne M Besser - Center for International Blood and Marrow Transplant ResearchJohn P Miller - National Marrow Donor ProgramRebecca J Drexler - Center for International Blood and Marrow Transplant ResearchAly Abdel-Mageed - Boston Children's HospitalIbrahim A Ahmed - Children's Mercy HospitalLuke P Akard - Indiana Blood and Marrow Transplantation, Indianapolis, INAndrew S Artz - University of ChicagoEdward D Ball - University of California, San DiegoRuthee-Lu Bayer - North Shore University HospitalCarolyn Bigelow - University of Mississippi Medical CenterBrian J Bolwell - Cleveland ClinicE Randolph Broun - Jewish HospitalDavid C Delgado - Riley Hospital for ChildrenKatharine Duckworth - Atrium Health Wake Forest BaptistChristopher C Dvorak - University of California, San FranciscoTheresa E Hahn - Roswell Park Cancer InstituteAnn E Haight - Emory UniversityParameswaran N Hari - Medical College of WisconsinBrandon M Hayes-Lattin - Oregon Health & Science UniversityDavid A Jacobsohn - Children's NationalAnn A Jakubowski - Memorial Sloan Kettering Cancer CenterKimberly A Kasow - University of North Carolina at Chapel HillHillard M Lazarus - University Hospitals of ClevelandJane L Liesveld - University of Rochester Medical CenterMichael Linenberger - Fred Hutch Cancer CenterMark R Litzow - Mayo ClinicWalter Longo - UW Health University HospitalMargarida Magalhaes-Silverman - University of IowaJohn M McCarty - Virginia Commonwealth UniversityJoseph P McGuirk - University of KansasShahram Mori - Florida Hospital Cancer Institute, Florida Center for Cellular Therapy, Orlando, FLVinod Parameswaran - Avera McKennan Transplant Institute, Sioux Falls, SDVinod K Prasad - Duke UniversityScott D Rowley - Hackensack University Medical CenterWitold B Rybka - Penn State Milton S. Hershey Medical CenterIndira Sahdev - Cohen Children's Medical CenterJeffrey R Schriber - Cancer Transplant Institute Honor Health, Scottsdale, AZGeorge B Selby - University of OklahomaPaul J Shaughnessy - Texas Transplant Institute, San Antonio, TXShalini Shenoy - St. Louis Children's HospitalThomas Spitzer - Harvard UniversityWilliam T Tse - Lurie Children's HospitalJoseph P Uberti - The Barbara Ann Karmanos Cancer InstituteMadhuri Vusirikala - The University of Texas Southwestern Medical CenterEdmund K Waller - Emory University HospitalDaniel J Weisdorf - University of MinnesotaGregory A Yanik - University of MichiganWillis H Navarro - Center for International Blood and Marrow Transplant ResearchMary M Horowitz - Medical College of WisconsinGalen E Switzer - University of PittsburghDennis L Confer - Center for International Blood and Marrow Transplant ResearchBronwen E Shaw - Medical College of Wisconsin
- Resource Type
- Journal article
- Publication Details
- Haematologica (Roma), Vol.104(4), pp.844-854
- DOI
- 10.3324/haematol.2018.200121
- PMID
- 30381298
- PMCID
- PMC6442962
- NLM abbreviation
- Haematologica
- ISSN
- 0390-6078
- eISSN
- 1592-8721
- Grant note
- R01 CA188523 / NCI NIH HHS U24 HL138660 / NHLBI NIH HHS U24 CA076518 / NCI NIH HHS R01 HL085707 / NHLBI NIH HHS UG1 HL069254 / NHLBI NIH HHS
- Language
- English
- Date published
- 04/2019
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984359831702771
Metrics
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