Journal article
Relating Intrinsic Low-Frequency BOLD Cortical Oscillations to Cognition in Schizophrenia
Neuropsychopharmacology (New York, N.Y.), Vol.40(12), pp.2705-2714
11/2015
DOI: 10.1038/npp.2015.119
PMCID: PMC4864646
PMID: 25944410
Abstract
The amplitude of low-frequency fluctuations (ALFF) in the blood oxygenation level-dependent (BOLD) signal during resting-state fMRI reflects the magnitude of local low-frequency BOLD oscillations, rather than interregional connectivity. ALFF is of interest to studies of cognition because fluctuations in spontaneous intrinsic brain activity relate to, and possibly even constrain, task-evoked brain responses in healthy people. Lower ALFF has been reported in schizophrenia, but the cognitive correlates of these reductions remain unknown. Here, we assess relationships between ALFF and attention and working memory in order to establish the functional relevance of intrinsic BOLD oscillatory power alterations with respect to specific cognitive impairments in schizophrenia. As part of the multisite FBIRN study, resting-state fMRI data were collected from schizophrenia subjects (SZ; n=168) and healthy controls (HC; n=166). Voxelwise fractional ALFF (fALFF), a normalized ALFF measure, was regressed on neuropsychological measures of sustained attention and working memory in SZ and HC to identify regions showing either common slopes across groups or slope differences between groups (all findings p<0.01 height, p<0.05 family-wise error cluster corrected). Poorer sustained attention was associated with smaller fALFF in the left superior frontal cortex and bilateral temporoparietal junction in both groups, with additional relationships in bilateral posterior parietal, posterior cingulate, dorsal anterior cingulate (ACC), and right dorsolateral prefrontal cortex (DLPFC) evident only in SZ. Poorer working memory was associated with smaller fALFF in bilateral ACC/mPFC, DLPFC, and posterior parietal cortex in both groups. Our findings indicate that smaller amplitudes of low-frequency BOLD oscillations during rest, measured by fALFF, were significantly associated with poorer cognitive performance, sometimes similarly in both groups and sometimes only in SZ, in regions known to subserve sustained attention and working memory. Taken together, these data suggest that the magnitude of resting-state BOLD oscillations shows promise as a biomarker of cognitive function in health and disease.
Details
- Title: Subtitle
- Relating Intrinsic Low-Frequency BOLD Cortical Oscillations to Cognition in Schizophrenia
- Creators
- Susanna L Fryer - San Francisco VA Medical Center, San Francisco, CA, USABrian J Roach - San Francisco VA Medical Center, San Francisco, CA, USAJudith M Ford - San Francisco VA Medical Center, San Francisco, CA, USAJessica A Turner - The Mind Research Network, Albuquerque, NM, USATheo G M van Erp - Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, USAJames Voyvodic - Department of Psychiatry, Duke University, Raleigh-Durham, NC, USAAdrian Preda - Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, USAAysenil Belger - Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USAJuan Bustillo - Department of Psychiatry, University of New Mexico, Albuquerque, NM, USADaniel O'Leary - Department of Psychiatry, University of Iowa, Iowa City, IA, USABryon A Mueller - Department of Psychiatry, University of Minnesota, Minneapolis, MN, USAKelvin O Lim - Department of Psychiatry, University of Minnesota, Minneapolis, MN, USASarah C McEwen - Department of Psychiatry, University of California, Los Angeles, Los Angeles, CA, USAVince D Calhoun - Department of Electrical and Computer Engineering, University of New Mexico, Albuquerque, NM, USAMichelle Diaz - Department of Psychiatry, Duke University, Raleigh-Durham, NC, USAGary Glover - Department of Radiology, Stanford University, Stanford, CA, USADouglas Greve - Department of Radiology, Massachusetts General Hospital, Boston, MA, USACynthia G Wible - VA Boston Healthcare System, Brockton, MA, USAJatin Vaidya - Department of Psychiatry, University of Iowa, Iowa City, IA, USASteven G Potkin - Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, USADaniel H Mathalon - San Francisco VA Medical Center, San Francisco, CA, USA
- Resource Type
- Journal article
- Publication Details
- Neuropsychopharmacology (New York, N.Y.), Vol.40(12), pp.2705-2714
- Publisher
- England
- DOI
- 10.1038/npp.2015.119
- PMID
- 25944410
- PMCID
- PMC4864646
- ISSN
- 0893-133X
- eISSN
- 1740-634X
- Grant note
- K01 MH099431 / NIMH NIH HHS IK2 CX001028 / CSRD VA UL1 TR001449 / NCATS NIH HHS U24 RR021992 / NCRR NIH HHS
- Language
- English
- Date published
- 11/2015
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute; University College Courses
- Record Identifier
- 9984070638902771
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