Journal article
Relation of Blood Pressure in Childhood to Self-Reported Hypertension in Adulthood: the International Childhood Cardiovascular Cohort (i3C) Consortium
Hypertension (Dallas, Tex. 1979), Vol.73(6), pp.1224-1230
06/01/2019
DOI: 10.1161/HYPERTENSIONAHA.118.12334
PMCID: PMC6510248
PMID: 31067199
Abstract
Blood pressure (BP) tracking (maintaining a BP percentile) across life is not well defined but is important in predicting which children will become hypertensive adults. We computed BP tracking in subjects with BP measured in childhood and adulthood and performed logistic regression to determine the ability of childhood BP to predict adult hypertension (N=5035, 46.7 years, 74.2% white, 17.7% black; 39.6% male). Prevalence of hypertension was 29%. Correlations between systolic BP for child and adolescent were r=0.48; adolescent and young adult r=0.40, and child and young adult r=0.24 (all p<0.0001). Participants self-reporting adult hypertension were less likely to be white (38.7% black, 27.6% white, 20.9% other; p<0.0001) and female (26.4% females, 32.9% male, p<0.0001). Participants with adult hypertension were more likely to have higher BP and adiposity by age 10 years and abnormal lipids and glucose by age 16 years. There was a graded increase in the frequency of self-reported adult hypertension across the BP change groups, even within the persistently normotensive group (X
2
< 0.0001) from 19% in children with a systolic BP % persistently below the median to 80% for individuals with elevated BP in both childhood and adolescence. Although our precision to predict which individual child is at risk of adult BP-related cardiovascular disease is weak, an increase in systolic BP and body mass index percentile from childhood to adolescence should signal a need for lifestyle intervention to prevent future sustained hypertension-related cardiovascular disease.
Details
- Title: Subtitle
- Relation of Blood Pressure in Childhood to Self-Reported Hypertension in Adulthood: the International Childhood Cardiovascular Cohort (i3C) Consortium
- Creators
- Elaine M. Urbina - Cincinnati Children's Hospital Medical CenterPhilip R. Khoury - Cincinnati Children's Hospital Medical CenterLydia Bazzano - Tulane UniversityTrudy L. Burns - University of IowaWei Chen - University of New OrleansStephen Daniels - University of Colorado DenverTerrence Dwyer - George Institute for Global HealthTian Hu - University of MinnesotaDavid R. Jacobs - University of MinnesotaMarkus Juonala - Turku University HospitalRonald Prineas - Wake Forest UniversityOlli Raitakari - Turku University HospitalJulia Steinberger - University of MinnesotaAlison Venn - University of TasmaniaJessica G. Woo - University of CincinnatiAlan Sinaiko - University of Minnesota Medical Center
- Resource Type
- Journal article
- Publication Details
- Hypertension (Dallas, Tex. 1979), Vol.73(6), pp.1224-1230
- DOI
- 10.1161/HYPERTENSIONAHA.118.12334
- PMID
- 31067199
- PMCID
- PMC6510248
- ISSN
- 0194-911X
- eISSN
- 1524-4563
- Language
- English
- Date published
- 06/01/2019
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984363600502771
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