Journal article
Relation of Intra-Articular Mineralization to Knee Pain in Knee Osteoarthritis: A Longitudinal Analysis in the MOST Study
Arthritis & Rheumatology, Vol.75(12), pp.2161-2168
12/01/2023
DOI: 10.1002/art.42649
PMCID: PMC10770289
PMID: 37410792
Abstract
OBJECTIVE: Intra-articular (IA) calcium crystal deposition is common in knee osteoarthritis (OA), but of unclear significance. It is possible that low-grade, crystal-related inflammation may contribute to knee pain. We examined the longitudinal relation of computed tomography (CT)-detected IA mineralization to the development of knee pain. METHODS: We used data from the National Institutes of Health-funded longitudinal Multicenter Osteoarthritis Study. Participants had knee radiographs and bilateral knee CTs at baseline, and pain assessments every 8 months for 2 years. CT images were scored using the Boston University Calcium Knee Score. We longitudinally examined the relation of CT-detected IA mineralization to the risk of frequent knee pain (FKP), intermittent or constant knee pain worsening, and pain severity worsening using generalized linear mixed-effects models. RESULTS: We included 2,093 participants (mean age 61 years, 57% women, mean body mass index 28.8 kg/m2 ). Overall, 10.2% of knees had IA mineralization. The presence of any IA mineralization in the cartilage was associated with 2.0 times higher odds of having FKP (95% confidence interval [CI] 1.38-2.78) and 1.86 times more frequent intermittent or constant pain (95% CI 1.20-2.78), with similar results seen for the presence of any IA mineralization in the meniscus or joint capsule. A higher burden of IA mineralization anywhere within the knee was associated with a higher odds of all pain outcomes (odds ratio ranged from 2.14 to 2.21). CONCLUSION: CT-detected IA mineralization was associated with risk of having more frequent, persistent, and worsening knee pain over 2 years. Targeting IA mineralization may have therapeutic potential for pain improvement in knee OA.
Details
- Title: Subtitle
- Relation of Intra-Articular Mineralization to Knee Pain in Knee Osteoarthritis: A Longitudinal Analysis in the MOST Study
- Creators
- Jean Liew - Boston University School of MedicineMohamed Jarraya - Massachusetts General HospitalAli Guermazi - Boston University School of MedicineJohn Lynch - University of California, San FranciscoNa Wang - Boston UniversityGabriela Rabasa - Boston UniversityS Jafarzadeh - Boston University School of MedicineMichael Nevitt - University of California, San FranciscoJames Torner - University of IowaCora Lewis - University of Alabama at BirminghamDavid Felson - Boston University School of MedicineTuhina Neogi - Boston University School of Medicine
- Resource Type
- Journal article
- Publication Details
- Arthritis & Rheumatology, Vol.75(12), pp.2161-2168
- DOI
- 10.1002/art.42649
- PMID
- 37410792
- PMCID
- PMC10770289
- NLM abbreviation
- Arthritis Rheumatol
- ISSN
- 2326-5191
- eISSN
- 2326-5205
- Publisher
- Wiley; HOBOKEN
- Grant note
- The authors acknowledge the Boston Musculoskeletal Clinical Research Collaboratory Research ACCELERATOR group for their insightful comments on this manuscript.
The authors acknowledge the Boston Musculoskeletal Clinical Research Collaboratory Research ACCELERATOR group for their insightful comments on this manuscript.
- Language
- English
- Date published
- 12/01/2023
- Academic Unit
- Neurology; Epidemiology; Injury Prevention Research Center; Neurosurgery
- Record Identifier
- 9984758181502771
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