Journal article
Relation of MRI‐Detected Features of Patellofemoral Osteoarthritis to Pain, Performance‐Based Function, and Daily Walking: The Multicenter Osteoarthritis Study
ACR open rheumatology, Vol.4(2), pp.161-167
11/18/2021
DOI: 10.1002/acr2.11361
PMCID: PMC8843751
PMID: 34792868
Abstract
Objective
The study objective was to determine the relationship of magnetic resonance imaging (MRI)-detected features of patellofemoral joint osteoarthritis to pain and functional outcomes.
Methods
We sampled 1,099 participants from the 60-month visit of the Multicenter Osteoarthritis Study (mean ± SD age: 66.8 ± 7.5 years; body mass index: 29.6 ± 4.8; 65% female). We determined the prevalence of MRI-detected features of patellofemoral joint osteoarthritis (eg, cartilage damage, bone marrow lesions, and osteophytes) and assessed the relationship between these features and knee pain severity, knee pain on stairs, chair stand time, and walking less than 6,000 steps per day. We evaluated the relationship of MRI features to each outcome using logistic and linear regression, adjusting for potential covariates.
Results
Participants with cartilage damage in 3-4 subregions had the highest mean pain severity (22.0/100; 95% confidence interval [CI]: 17.6-26.4 mm). They also showed higher odds of having at least mild pain on stairs (odds ratio [OR]: 3.3; 95% CI: 1.7-6.5) and of walking less than 6,000 steps per day (OR: 2.3; 95% CI: 1.1-4.4) compared with those without cartilage damage. Participants with bone marrow lesions in 3-4 subregions had higher odds of at least mild pain on stairs than those without (OR: 3.3; 95% CI: 2.2-5.2). Participants with osteophytes in 3-4 subregions also had higher odds of walking less than 6,000 steps/day (OR 2.1, 95% CI: 1.3-3.5, respectively).
Conclusion
MRI-detected features of osteoarthritis of the patellofemoral joint are related to pain and functional performance. This knowledge highlights the need to develop treatments for those with patellofemoral joint osteoarthritis to improve pain and maximize function.
Details
- Title: Subtitle
- Relation of MRI‐Detected Features of Patellofemoral Osteoarthritis to Pain, Performance‐Based Function, and Daily Walking: The Multicenter Osteoarthritis Study
- Creators
- J. L Maxwell - Department of Physical Therapy, Movement and Rehabilitation Sciences Northeastern University Boston MassachusettsT Neogi - Department of Medicine, Section of Rheumatology Boston University School of Medicine Boston MassachusettsKay M Crossley - La Trobe Sport and Exercise Medicine Research Centre La Trobe University Bundoora AustraliaErin M Macri - Departments of General Practice, Orthopaedics and Sports Medicine Erasmus University Medical Centre Rotterdam NetherlandsDan White - Department of Physical Therapy University of Delaware Newark DelawareA Guermazi - Department of Radiology VA Boston Healthcare System West Roxbury Massachusetts, Quantitative Imaging Center (QIC), Department of Radiology Boston University School of Medicine Boston MassachusettsF. W Roemer - Department of Radiology University of Erlangen‐Nuremberg Erlangen GermanyM. C Nevitt - Department of Epidemiology and Biostatistics University of California San Francisco San Francisco CaliforniaC. E Lewis - Division of Preventive Medicine University of Alabama at Birmingham Birmingham AlabamaJ. C Torner - Department of Epidemiology The University of Iowa Iowa City IowaJ. J Stefanik - Department of Physical Therapy, Movement and Rehabilitation Sciences Northeastern University Boston Massachusetts
- Resource Type
- Journal article
- Publication Details
- ACR open rheumatology, Vol.4(2), pp.161-167
- DOI
- 10.1002/acr2.11361
- PMID
- 34792868
- PMCID
- PMC8843751
- NLM abbreviation
- ACR Open Rheumatol
- ISSN
- 2578-5745
- eISSN
- 2578-5745
- Language
- English
- Date published
- 11/18/2021
- Academic Unit
- Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
- Record Identifier
- 9984214806402771
Metrics
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