Journal article
Relation of forward and backward traveling pressure waves with subclinical carotid artery wall remodeling and central pulse pressure
Journal of applied physiology (1985), Vol.135(4), pp.943-949
10/2023
DOI: 10.1152/japplphysiol.00286.2023
PMCID: PMC10642512
PMID: 37650141
Abstract
Central pulse pressure (PP) is the sum of a forward and backward traveling pressure waves which have been associated with cardiovascular disease (CVD) risk. However, previous studies have reported differential findings regarding importance of the forward versus the backward wave for CVD risk. Therefore, we sought to determine the degree to which the forward and backward pressure waves are associated with subclinical carotid artery wall remodeling and central PP in healthy adults. Using applanation tonometry, carotid pressure waveforms were acquired in 308 healthy individuals (aged 45±17 years, range 19-80 years, 61% women), from which the time integral of the forward (PfTI) and backward (PbTI) pressure waves were derived via pressure-only wave separation analysis. Common carotid artery intima-media thickness (cIMT), a biomarker of subclinical CVD risk, was derived via B-mode ultrasonography measured ~2 cm from the carotid bulb. Both PfTI (r=0.31, P<0.001) and PbTI (r=0.40, P<0.001) were correlated with cIMT. However, further analysis revealed that PbTI mediated the relation between PfTI and cIMT (proportion mediated=156%, P<0.001). The association between PbTI and cIMT remained after adjusting for age, sex, body mass index, blood glucose, low-density lipoprotein cholesterol, heart rate, brachial systolic pressure, and aortic stiffness (B=0.02, 95% confidence interval=0.01, 2.77, P<0.001). Both PfTI (r=-0.58, P<0.001) and PbTI (r=-0.50, P<0.001) were correlated with central PP, however, PfTI fully mediated the association between PbTI and central PP (proportion mediated=124%, P<0.001). Although PfTI is correlated with higher central PP, it is PbTI that is directly associated with carotid artery wall remodeling.
Details
- Title: Subtitle
- Relation of forward and backward traveling pressure waves with subclinical carotid artery wall remodeling and central pulse pressure
- Creators
- Matthew K Armstrong - University of IowaVirginia R Nuckols - University of IowaColin J Gimblet - University of IowaRachel E Luehrs - North Central CollegeAbbi D Lane - University of MichiganJulio A Chirinos - University of PennsylvaniaMichelle W Voss - University of IowaGary L Pierce - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of applied physiology (1985), Vol.135(4), pp.943-949
- DOI
- 10.1152/japplphysiol.00286.2023
- PMID
- 37650141
- PMCID
- PMC10642512
- NLM abbreviation
- J Appl Physiol (1985)
- ISSN
- 8750-7587
- eISSN
- 1522-1601
- Grant note
- DOI: 10.13039/100000968, name: American Heart Association, award: 19TPA34910016, 18SCG34350001, 17POST33440101, 13SDG14300012; DOI: 10.13039/100000002, name: HHS | National Institutes of Health, award: AG063790, HL014388, HL07121, AG043722, AG048170, AG055500, RR024980-05; DOI: 10.13039/100000002, name: HHS | National Institutes of Health, award: T32DK007690; DOI: 10.13039/100006108, name: HHS | NIH | National Center for Advancing Translational Sciences, award: UL1TR002537; DOI: 10.13039/100008893, name: University of Iowa, award: Russell B. Day and Florence D. Day Endowed Chair in Liberal Arts and Sciences
- Language
- English
- Electronic publication date
- 08/31/2023
- Date published
- 10/2023
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute; Health, Sport, and Human Physiology ; Internal Medicine
- Record Identifier
- 9984461800802771
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