Journal article
Relation of meniscus pathology to prevalence and worsening of patellofemoral joint osteoarthritis: the Multicenter Osteoarthritis Study
Osteoarthritis and cartilage, Vol.26(7), pp.912-919
07/2018
DOI: 10.1016/j.joca.2017.11.017
PMCID: PMC6005722
PMID: 29427724
Abstract
To determine the relationship of meniscal damage to magnetic resonance imaging (MRI) features of compartment-specific patellofemoral joint (PFJ) osteoarthritis (OA) at baseline and 2 years later.
Individuals from a prospective cohort of individuals aged 50–79 with or at risk of knee OA were included. At the 60-month and 84-month study visit, Whole-Organ MRI Score (WORMS) was used to assess meniscal tears and extrusions as well as cartilage damage and bone marrow lesions (BMLs) in the medial and lateral patella and trochlea. Worsening of structural features was defined as any increase in WORMS score from 60 to 84 months. Logistic regression was used to determine the cross-sectional and longitudinal relation of meniscus damage to features of compartment-specific PFJ OA.
Relative to knees without lateral meniscal pathology at baseline, those with grades 3–4 lateral meniscal tear and extrusion had greater risk of worsening of cartilage damage in the lateral PFJ 2 years later (Risk ratio: 1.7 [95% CI: 1.1–2.7) and (1.7 [1.2–2.5]), respectively. Relative to those without medial meniscal pathology at baseline, those with grades 1–2 (0.6 [0.4–0.9]) and 3–4 (0.7 [0.5–1.0]) medial meniscal tears had lower risk of worsening of BMLs in the medial PFJ 2 years later.
Meniscal tear and extrusion are associated with increased risk of medial and lateral PFJ OA and more severe meniscal pathology is associated with worsening of PFJ OA 2 years later. Lateral meniscal pathology appears to be more detrimental to the lateral PFJ.
Details
- Title: Subtitle
- Relation of meniscus pathology to prevalence and worsening of patellofemoral joint osteoarthritis: the Multicenter Osteoarthritis Study
- Creators
- H.F Hart - La Trobe Sport and Exercise Medicine Research Centre, School of Allied Health, La Trobe University, Bundoora, Victoria, AustraliaK.M Crossley - La Trobe Sport and Exercise Medicine Research Centre, School of Allied Health, La Trobe University, Bundoora, Victoria, AustraliaD Felson - Boston University, School of Medicine, Boston, USAM Jarraya - Mercy Catholic Medical Center, Darby, USAA Guermazi - Boston University, School of Medicine, Boston, USAF Roemer - Boston University, School of Medicine, Boston, USAC.E Lewis - University of Alabama at Birmingham, Birmingham, USAJ Torner - University of Iowa, Iowa City, USAM Nevitt - University of California San Francisco, San Francisco, USAJ.J Stefanik - Boston University, School of Medicine, Boston, USA
- Resource Type
- Journal article
- Publication Details
- Osteoarthritis and cartilage, Vol.26(7), pp.912-919
- DOI
- 10.1016/j.joca.2017.11.017
- PMID
- 29427724
- PMCID
- PMC6005722
- NLM abbreviation
- Osteoarthritis Cartilage
- ISSN
- 1063-4584
- eISSN
- 1522-9653
- Publisher
- Elsevier Ltd
- Grant note
- name: NIH, award: P60 AR047785, UO1 AG18820, UO1 AG18832, UO1 AG18947, UO1 AG19069; name: National Health and Medical Research Council (Australia) Project, award: GNT1106852
- Language
- English
- Date published
- 07/2018
- Academic Unit
- Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
- Record Identifier
- 9983995163802771
Metrics
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