Journal article
Relation of vitamin A and carotenoid status to growth failure and mortality among ugandan infants with human immunodeficiency virus
Nutrition (Burbank, Los Angeles County, Calif.), Vol.17(7), pp.567-572
2001
DOI: 10.1016/S0899-9007(01)00567-6
PMID: 11448574
Abstract
Although growth failure is common during pediatric infection with human immunodeficiency virus (HIV) and associated with increased mortality, the relation of specific nutrition factors with growth and mortality has not been well characterized. A longitudinal study was conducted with 194 HIV-infected infants in Kampala, Uganda. Plasma vitamin A, carotenoids (α-carotene, β-carotene, β-cryptoxanthin, lycopene, and lutein/zeaxanthin), and vitamin E were measured at age 14 wk, and weight and height were followed up to age 12 mo. Vitamin A and low plasma carotenoid concentrations were predictive of decreased weight and height velocity. Between ages 14 wk and 12 mo, 32% of infants died. Underweight, stunting, and low concentrations of plasma carotenoids were associated with increased risk of death in univariate analyses. Plasma vitamin A concentrations were not associated with risk of death. In a final multivariate model adjusting for weight-for-age, plasma β-carotene was significantly associated with increased mortality (odds ratio: 3.16, 95% confidence interval: 1.38 to 7.21,
P < 0.006). These data suggest that low concentrations of plasma carotenoids are associated with increased risk of death during HIV infection among infants in Uganda.
Details
- Title: Subtitle
- Relation of vitamin A and carotenoid status to growth failure and mortality among ugandan infants with human immunodeficiency virus
- Creators
- George Melikian - Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USAFrancis Mmiro - Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USAChristopher Ndugwa - Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USARobert Perry - Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USAJ.Brooks Jackson - Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USAElizabeth Garrett - Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USAJames Tielsch - Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USARichard D Semba - Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
- Resource Type
- Journal article
- Publication Details
- Nutrition (Burbank, Los Angeles County, Calif.), Vol.17(7), pp.567-572
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S0899-9007(01)00567-6
- PMID
- 11448574
- ISSN
- 0899-9007
- eISSN
- 1873-1244
- Language
- English
- Date published
- 2001
- Academic Unit
- Pathology; VPMA - Administration
- Record Identifier
- 9984047654902771
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