Journal article
Relations of Dietary Magnesium Intake to Biomarkers of Inflammation and Endothelial Dysfunction in an Ethnically Diverse Cohort of Postmenopausal Women
Diabetes care, Vol.33(2), pp.304-310
02/01/2010
DOI: 10.2337/dc09-1402
PMCID: PMC2809271
PMID: 19903755
Abstract
OBJECTIVE - Although magnesium may favorably affect metabolic outcomes, few studies have investigated the role of magnesium intake in systemic inflammation and endothelial dysfunction in humans.
RESEARCH DESIGN AND METHODS - Among 3,713 postmenopausal women aged 50-79 years in the Women's Health Initiative Observational Study and free of cardiovascular disease, cancer, and diabetes at baseline, we measured plasma concentrations of high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), turnor necrosis factor-alpha receptor 2 (TNF-alpha-R2), soluble intercellular adhesion molecule-1 (sICAM-1), soluble Vascular cell adhesion molecule-.1. (sVC-AM-1), and E-selectin. Magnesium intake was assessed using a semiquantitative food frequency questionnaire.
RESULTS - After adjustment for age, ethnicity, clinical center, time of blood draw, smoking, alcohol, physical activity, energy intake, BMI, and diabetes status, magnesium intake was inversely associated with hs-CRP (P for linear trend = 0.003), IL-6 (P < 0.0001), TNF-alpha-R2 (P = 0.0006), and sVCAM-1 (P = 0.06). Similar findings remained after further adjustment for dietary fiber, fruit, vegetables, folate, and saturated and trans fat intake. Multivariable-adjusted geometric means across increasing quintiles of magnesium intake were 3.08, 2.63, 2.31, 2.53, and 2.16 mg/l for hs-CRP (P = 0.005); 2.91, 2.63, 2.45, 2.27, and 2.26 pg/ml for IL-6 (P = 0.0005); and 707, 681, 673, 671, and 656 ng/ml for sVCAM-1 (P = 0.04). An increase of 100 mg/day magnesium was inversely associated with hs-CRP (-0.23 mg/l +/- 0.07; P = 0.002), IL-6 (-0.14 +/- 0.05 pg/ml; P = 0.004), TNF-alpha-R2 (-0.04 +/- 0.02 pg/ml; P = 0.06), and sVCAM-1 (-0.04 +/- 0.02 ng/ml; P = 0.07). No significant ethnic differences were observed.
CONCLUSIONS- High magnesium intake is associated with lower concentrations of certain markers of systemic inflammation and endothelial dysfunction in postmenopausal women.
Details
- Title: Subtitle
- Relations of Dietary Magnesium Intake to Biomarkers of Inflammation and Endothelial Dysfunction in an Ethnically Diverse Cohort of Postmenopausal Women
- Creators
- Sara A. Chacko - University of California, Los AngelesYiqing Song - Harvard UniversityLauren Nathan - David Geffen School of Medicine at UCLALesley Tinker - Fred Hutch Cancer CenterIan H. de Boer - University of WashingtonFran Tylavsky - University of Tennessee at KnoxvilleRobert Wallace - University of IowaSimin Liu - University of California, Los Angeles
- Resource Type
- Journal article
- Publication Details
- Diabetes care, Vol.33(2), pp.304-310
- DOI
- 10.2337/dc09-1402
- PMID
- 19903755
- PMCID
- PMC2809271
- NLM abbreviation
- Diabetes Care
- ISSN
- 0149-5992
- eISSN
- 1935-5548
- Publisher
- Amer Diabetes Assoc
- Number of pages
- 7
- Grant note
- ROI-DK-062290; K01-DK-078846 / National Institute of Diabetes and Digestive and Kidney Diseases, NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) National Heart, Lung, and Blood Institute, National Institutes of Health (NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) Burroughs Wellcome Fund Institutional Program Unifying Population and Laboratory-Based Sciences; Burroughs Wellcome Fund N01WH022110 / WOMEN'S HEALTH INITIATIVE - OFFICE OF THE DIRECTOR NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01DK062290 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) N01-WH-22110; 24152; 32100-2; 32105-6; 32108-9; 32111-13; 32115; 32118-32119; 32122; 42107-26; 42129-32; 44221 / U.S, Department of Health and Human Services
- Language
- English
- Date published
- 02/01/2010
- Academic Unit
- Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984363598002771
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