Journal article
Relationship Between 24-Hour Ambulatory Blood Pressure and Cognitive Function in Community-Living Older Adults: The UCSD Ambulatory Blood Pressure Study
American journal of hypertension, Vol.28(12), pp.1444-1452
12/2015
DOI: 10.1093/ajh/hpv042
PMCID: PMC4654763
PMID: 25896923
Abstract
BACKGROUND
Twenty-four-hour ambulatory blood pressure (BP) patterns have been associated with diminished cognitive function in hypertensive and very elderly populations. The relationship between ambulatory BP patterns and cognitive function in community-living older adults is unknown.
METHODS
We conducted a cross-sectional study in which 24-hour ambulatory BP, in-clinic BP, and cognitive function measures were obtained from 319 community-living older adults.
RESULTS
The mean age was 72 years, 66% were female, and 13% were African-American. We performed linear regression with performance on the Montreal Cognitive Assessment (MoCA) as the primary outcome and 24-hour BP patterns as the independent variable, adjusting for age, sex, race/ethnicity, education, and comorbidities. Greater nighttime systolic dipping (P = 0.046) and higher 24-hour diastolic BP (DBP; P = 0.015) were both significantly associated with better cognitive function, whereas 24-hour systolic BP (SBP), average real variability, and ambulatory arterial stiffness were not.
CONCLUSIONS
Higher 24-hour DBP and greater nighttime systolic dipping were significantly associated with improved cognitive function. Future studies should examine whether low 24-hour DBP and lack of nighttime systolic dipping predict future cognitive impairment.
Details
- Title: Subtitle
- Relationship Between 24-Hour Ambulatory Blood Pressure and Cognitive Function in Community-Living Older Adults: The UCSD Ambulatory Blood Pressure Study
- Creators
- Kyle S Conway - University of California, San DiegoNketi Forbang - University of California, San DiegoTomasz Beben - University of California, San DiegoMichael H Criqui - University of California, San DiegoJoachim H Ix - University of California, San DiegoDena E Rifkin - University of California, San Diego
- Resource Type
- Journal article
- Publication Details
- American journal of hypertension, Vol.28(12), pp.1444-1452
- Publisher
- Oxford University Press
- DOI
- 10.1093/ajh/hpv042
- PMID
- 25896923
- PMCID
- PMC4654763
- ISSN
- 0895-7061
- eISSN
- 1879-1905
- Language
- English
- Date published
- 12/2015
- Academic Unit
- Pathology
- Record Identifier
- 9984186283402771
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