Relationship between HER-2 overexpression and brain metastasis in esophageal cancer patients

Taher Abu Hejleh; Barry R DeYoung; Eric Engelman; Jeremy M Deutsch; Bridget Zimmerman; Thorvardur R Halfdanarson; Daniel J Berg; Kalpaj R Parekh; William R Lynch; Mark D Iannettoni; Sudershan Bhatia; Gerald Clamon

doi:10.4251/wjgo.v4.i5.103

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Relationship between HER-2 overexpression and brain metastasis in esophageal cancer patients

Journal article

Open access

Peer reviewed

Relationship between HER-2 overexpression and brain metastasis in esophageal cancer patients

Taher Abu Hejleh, Barry R DeYoung, Eric Engelman, Jeremy M Deutsch, Bridget Zimmerman, Thorvardur R Halfdanarson, Daniel J Berg, Kalpaj R Parekh, William R Lynch, Mark D Iannettoni, …

World journal of gastrointestinal oncology, Vol.4(5), pp.103-108

05/15/2012

DOI: 10.4251/wjgo.v4.i5.103

PMCID: PMC3360103

PMID: 22645633

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https://doi.org/10.4251/wjgo.v4.i5.103View

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Abstract

AIM: To study if HER-2 overexpression by locally advanced esophageal cancers increase the chance of brain metastasis following esophagectomy. METHODS: We retrospectively reviewed the medical records of esophageal cancer patients who underwent esophagectomy at University of Iowa Hospitals and Clinics between 2000 and 2010. Data analyzed consisted of demographic and clinical variables. The brain metastasis tissue was assayed for HER-2 overexpression utilizing the FDA approved DAKO Hercept Test ® . RESULTS: One hundred and forty two patients were reviewed. Median age was 64 years (36-86 years). Eighty eight patients (62%) received neoadjuvant chemoradiotherapy. Pathological complete and partial responses were achieved in 17 (19%) and 71 (81%) patients. Cancer relapsed in 43/142 (30%) patients. The brain was the first site of relapse in 9/43 patients (21%, 95% CI: 10%-36%). HER-2 immunohistochemistry testing of the brain metastasis tissue showed that 5/9 (56%) cases overexpressed HER-2 (3+ staining). CONCLUSION: HER-2 overexpression might be associated with increased risk of brain metastasis in esophageal cancer patients following esophagectomy. Further studies will be required to validate this observation.

Esophageal neoplasm

Genes, erbB-2

Brain metastasis

Brief

HER-2

Esophageal cancer

Brain Neoplasms

Details

Title: Subtitle: Relationship between HER-2 overexpression and brain metastasis in esophageal cancer patients
Creators: Taher Abu Hejleh
Barry R DeYoung
Eric Engelman
Jeremy M Deutsch
Bridget Zimmerman
Thorvardur R Halfdanarson
Daniel J Berg
Kalpaj R Parekh
William R Lynch
Mark D Iannettoni
Sudershan Bhatia
Gerald Clamon
Resource Type: Journal article
Publication Details: World journal of gastrointestinal oncology, Vol.4(5), pp.103-108
DOI: 10.4251/wjgo.v4.i5.103
PMID: 22645633
PMCID: PMC3360103
NLM abbreviation: World J Gastrointest Oncol
ISSN: 1948-5204
eISSN: 1948-5204
Publisher: Baishideng Publishing Group Co., Limited
Language: English
Date published: 05/15/2012
Academic Unit: Anatomy and Cell Biology; Biostatistics; Surgery; Radiation Oncology; Internal Medicine
Record Identifier: 9983997997402771

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