Relationship between chronic nonurological associated somatic syndromes and symptom severity in urological chronic pelvic pain syndromes: baseline evaluation of the MAPP study

John N Krieger; Alisa J Stephens; J Richard Landis; J Quentin Clemens; Karl Kreder; H Henry Lai; Niloofar Afari; Larissa Rodríguez; Anthony Schaeffer; Sean Mackey; Gerald L Andriole; David A Williams

doi:10.1016/j.juro.2014.10.086

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Relationship between chronic nonurological associated somatic syndromes and symptom severity in urological chronic pelvic pain syndromes: baseline evaluation of the MAPP study

Journal article

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Relationship between chronic nonurological associated somatic syndromes and symptom severity in urological chronic pelvic pain syndromes: baseline evaluation of the MAPP study

John N Krieger, Alisa J Stephens, J Richard Landis, J Quentin Clemens, Karl Kreder, H Henry Lai, Niloofar Afari, Larissa Rodríguez, Anthony Schaeffer, Sean Mackey, …

The Journal of urology, Vol.193(4), pp.1254-1262

04/2015

DOI: 10.1016/j.juro.2014.10.086

PMCID: PMC4497586

PMID: 25444992

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Abstract

We used MAPP data to identify participants with urological chronic pelvic pain syndromes only or a chronic functional nonurological associated somatic syndrome in addition to urological chronic pelvic pain syndromes. We characterized these 2 subgroups and explored them using 3 criteria, including 1) MAPP eligibility criteria, 2) self-reported medical history or 3) RICE criteria. Self-reported cross-sectional data were collected on men and women with urological chronic pelvic pain syndromes, including predominant symptoms, symptom duration and severity, nonurological associated somatic syndrome symptoms and psychosocial factors. Of 424 participants with urological chronic pelvic pain syndromes 162 (38%) had a nonurological associated somatic syndrome, including irritable bowel syndrome in 93 (22%), fibromyalgia in 15 (4%), chronic fatigue syndrome in 13 (3%) and multiple syndromes in 41 (10%). Of 233 females 103 (44%) had a nonurological associated somatic syndrome compared to 59 of 191 males (31%) (p = 0.006). Participants with a nonurological associated somatic syndrome had more severe urological symptoms and more frequent depression and anxiety. Of 424 participants 228 (54%) met RICE criteria. Of 228 RICE positive participants 108 (47%) had a nonurological associated somatic syndrome compared to 54 of 203 RICE negative patients (28%) with a nonurological associated somatic syndrome (p < 0.001). Nonurological associated somatic syndromes represent important clinical characteristics of urological chronic pelvic pain syndromes. Participants with a nonurological associated somatic syndrome have more severe symptoms, longer duration and higher rates of depression and anxiety. RICE positive patients are more likely to have a nonurological associated somatic syndrome and more severe symptoms. Because nonurological associated somatic syndromes are more common in women, future studies must account for this potential confounding factor in urological chronic pelvic pain syndromes.

Severity of Illness Index

Cystitis, Interstitial - diagnosis

Cross-Sectional Studies

Humans

Symptom Assessment

Male

Cystitis, Interstitial - complications

Pelvic Pain - diagnosis

Syndrome

Pelvic Pain - psychology

Interdisciplinary Communication

Pelvic Pain - etiology

Female

Surveys and Questionnaires

Chronic Disease

Details

Title: Subtitle: Relationship between chronic nonurological associated somatic syndromes and symptom severity in urological chronic pelvic pain syndromes: baseline evaluation of the MAPP study
Creators: John N Krieger - Department of Urology, University of Washington, Seattle, Washington. Electronic address: jkrieger@uw.edu
Alisa J Stephens - Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
J Richard Landis - Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
J Quentin Clemens - Department of Urology, University of Michigan, Ann Arbor, Michigan
Karl Kreder - Department of Urology, University of Iowa Hospitals and Clinics, Iowa City, Iowa
H Henry Lai - Department of Surgery-Division of Urologic Surgery, Washington University St. Louis, St. Louis, Missouri
Niloofar Afari - Veterans Affairs Center of Excellence for Stress and Mental Health and University of California-San Diego, San Diego
Larissa Rodríguez - Department of Urology, University of California-Los Angeles, Los Angeles
Anthony Schaeffer - Department of Urology, Northwestern University, Chicago, Illinois
Sean Mackey - Department of Anesthesia-Division of Pain Management, Stanford University, Palo Alto, California
Gerald L Andriole - Department of Surgery-Division of Urologic Surgery, Washington University St. Louis, St. Louis, Missouri
David A Williams - Department of Urology, University of Michigan, Ann Arbor, Michigan
Resource Type: Journal article
Publication Details: The Journal of urology, Vol.193(4), pp.1254-1262
DOI: 10.1016/j.juro.2014.10.086
PMID: 25444992
PMCID: PMC4497586
NLM abbreviation: J Urol
ISSN: 0022-5347
eISSN: 1527-3792
Publisher: United States
Grant note: U01 DK082344 / NIDDK NIH HHS U01 DK082342 / NIDDK NIH HHS UL1 TR001082 / NCATS NIH HHS U01 DK082315 / NIDDK NIH HHS Z99 NS999999 / Intramural NIH HHS U01 DK082325 / NIDDK NIH HHS U01 DK082345 / NIDDK NIH HHS U01 DK082370 / NIDDK NIH HHS U01 DK082316 / NIDDK NIH HHS
Language: English
Date published: 04/2015
Academic Unit: Obstetrics and Gynecology; Urology
Record Identifier: 9984051713202771

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