Journal article
Relationship between endogenous concentrations of vasoactive substances and measures of peripheral vasodilator function in patients with coronary artery disease
Clinical and experimental pharmacology & physiology, Vol.37(1), pp.24-28
01/2010
DOI: 10.1111/j.1440-1681.2009.05225.x
PMID: 19515062
Abstract
1. The aim of the present study was to determine the relationship between plasma concentrations of nitrite/nitrate (NO(x)) and endothelin (ET)-1 and non-invasive measures of peripheral vasodilator function in patients with coronary artery disease (CAD). 2. Twenty-two patients with angiographic CAD underwent non-invasive measurement of peripheral vasodilator function in the brachial conduit artery (flow-mediated dilation (FMD) testing via ultrasound) and in the forearm resistance arteries (via venous occlusion plethysmography) during reactive hyperaemia after 5 min ischaemia. In addition, plasma NO(x) and ET-1 concentrations were determined. 3. The plasma concentration of NO(x) was related to the peak brachial FMD response when expressed as either the relative (%) or absolute (mm) change in diameter (r = 0.73, P < 0.001; and r = 0.64, P < 0.01, respectively). Moreover, plasma concentrations of NO(x) demonstrated a relationship with forearm vasodilation estimated by total forearm blood flow following 5 min ischaemia (r = 0.63, P < 0.01) and the flow debt repayment of the forearm (r = 0.54, P < 0.01). Finally, ET-1 concentrations were inversely related to FMD% (r = -0.45, P < 0.05). 4. The findings of the present study demonstrate a relationship between the plasma concentrations of NO(x) and measures of vascular reactivity in conduit and resistance arteries in patients with CAD. Therefore, measurement of plasma NO(x) may serve as a reliable marker for peripheral vasodilator dysfunction in patients with CAD.
Details
- Title: Subtitle
- Relationship between endogenous concentrations of vasoactive substances and measures of peripheral vasodilator function in patients with coronary artery disease
- Creators
- Darren P Casey - Department of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Center for Exercise Science, Gainesville, Florida, USA. casey.darren@mayo.eduWilmer W NicholsC Richard ContiRandy W Braith
- Resource Type
- Journal article
- Publication Details
- Clinical and experimental pharmacology & physiology, Vol.37(1), pp.24-28
- Publisher
- Australia
- DOI
- 10.1111/j.1440-1681.2009.05225.x
- PMID
- 19515062
- ISSN
- 0305-1870
- eISSN
- 1440-1681
- Grant note
- HL077571 / NHLBI NIH HHS R01 HL077571 / NHLBI NIH HHS
- Language
- English
- Date published
- 01/2010
- Academic Unit
- Physical Therapy and Rehabilitation Science; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984047897902771
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