Journal article
Relationship between plasma sodium concentration and vascular reactivity in man
The Journal of clinical investigation, Vol.50(10), pp.2022-2032
10/1971
DOI: 10.1172/JCI106695
PMCID: PMC292135
PMID: 4330003
Abstract
Experiments were done to study the effects of acute changes in plasma sodium concentration [Na] on vasoconstrictor responses to norepinephrine and to reflex sympathetic stimulation in man. [Na] in the venous return from the forearm of each of 21 normal subjects was reduced (to an average of 118 mEq/liter), increased (147 mEq/liter), and maintained within the normal range (140 mEq/liter) by means of infusions into the brachial artery of three solutions containing different [Na]. Mannitol or sucrose and disodium sulfate were substituted for sodium chloride to produce the desired changes in [Na] without changing blood osmolarity.
Blood flow to the forearm (plethysmograph) increased during infusion of the three solutions, but the increase in flow was not related to [Na]. Vasoconstrictor responses to injections of norepinephrine and angiotensin into the brachial artery were reduced at low [Na] and augmented at high [Na]. Reflex vasoconstriction, activated by lower body negative pressure, was similarly affected by changes in [Na]. In the isolated, perfused gracilis muscle of dog vasoconstrictor responses to norepinephrine and to nerve stimulation were attenuated, and the extraction of norepinephrine by this muscle was smaller when plasma [Na] was reduced.
Details
- Title: Subtitle
- Relationship between plasma sodium concentration and vascular reactivity in man
- Creators
- Donald D Heistad - Cardiovascular Division, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52240Francois M Abboud - Cardiovascular Division, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52240Dennis R Ballard - Cardiovascular Division, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52240
- Resource Type
- Journal article
- Publication Details
- The Journal of clinical investigation, Vol.50(10), pp.2022-2032
- DOI
- 10.1172/JCI106695
- PMID
- 4330003
- PMCID
- PMC292135
- ISSN
- 0021-9738
- eISSN
- 1558-8238
- Language
- English
- Date published
- 10/1971
- Academic Unit
- Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984025350202771
Metrics
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