Journal article
Relationship between prostate size and percent free prostate-specific antigen in patients with operable prostate cancer
The Israel Medical Association journal, Vol.2(12), pp.889-891
12/01/2000
PMID: 11344767
Abstract
Background: The free-to-total prostate-specific antigen ratio is the best marker for optimizing prostate cancer detection. The main problem with studies of percent free PSA is the variability of reported cutoff values.
Objectives: To evaluate the influence of prostate size on the ratio of free to total PSA.
Methods: The study group included 58 patients (mean age 66.4 years) with clinically localized prostate cancer treated surgically at our institution. Total PSA and free PSA levels were measured by a solid phase enzyme immunoassay test (Hoffman-La Roche, Basel, Switzerland). The percent free PSA was compared with prostate size as determined from the surgical specimen.
Results: A direct relation was noted between prostate size and the percent free PSA value (r=0.49, P=0.0001). Mean percentage free PSA was 9%+/-0.004 in men with normal-sized gland while in men with large prostate (>60 g) the average percent free PSA was 15.9+/-0.09 (P=0.001).
Conclusions: In patients with prostate cancer the percent free PSA level is influenced by the gland size. The larger the prostate the higher the proportion of the free PSA. Such information may have influence on the recommendation for prostate biopsy in screening programs for early detection of prostate cancer.
Details
- Title: Subtitle
- Relationship between prostate size and percent free prostate-specific antigen in patients with operable prostate cancer
- Creators
- O NativE SaboM WaldS HalachmiB Moskovitz
- Resource Type
- Journal article
- Publication Details
- The Israel Medical Association journal, Vol.2(12), pp.889-891
- Publisher
- Israel Medical Assoc Journal
- PMID
- 11344767
- ISSN
- 1565-1088
- Number of pages
- 3
- Language
- English
- Date published
- 12/01/2000
- Academic Unit
- Urology
- Record Identifier
- 9984320856302771
Metrics
13 Record Views