Journal article
Relationship between quantitative CT metrics and health status and BODE in chronic obstructive pulmonary disease
Thorax, Vol.67(5), pp.399-406
05/2012
DOI: 10.1136/thoraxjnl-2011-201185
PMCID: PMC3719874
PMID: 22514236
Abstract
BackgroundThe value of quantitative CT (QCT) to identify chronic obstructive pulmonary disease (COPD) phenotypes is increasingly appreciated. The authors hypothesised that QCT-defined emphysema and airway abnormalities relate to St George's Respiratory Questionnaire (SGRQ) and Body-Mass Index, Airflow Obstruction, Dyspnea and Exercise Capacity Index (BODE).Methods1200 COPDGene subjects meeting Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria for COPD with QCT analysis were included. Total lung emphysema was measured using the density mask technique with a −950 Hounsfield unit threshold. An automated programme measured mean wall thickness (WT), wall area percentage (WA%) and 10 mm lumenal perimeter (pi10) in six segmental bronchi. Separate multivariate analyses examined the relative influence of airway measures and emphysema on SGRQ and BODE.ResultsIn separate models predicting SGRQ score, a 1 unit SD increase in each airway measure predicted higher SGRQ scores (for WT, 1.90 points higher, p=0.002; for WA%, 1.52 points higher, p=0.02; for pi10, 2.83 points higher p<0.001). The comparable increase in SGRQ for a 1 unit SD increase in emphysema percentage in these models was relatively weaker, significant only in the pi10 model (for emphysema percentage, 1.45 points higher, p=0.01). In separate models predicting BODE, a 1 unit SD increase in each airway measure predicted higher BODE scores (for WT, 1.07-fold increase, p<0.001; for WA%, 1.20-fold increase, p<0.001; for pi10, 1.16-fold increase, p<0.001). In these models, emphysema more strongly influenced BODE (range 1.24–1.26-fold increase, p<0.001).ConclusionEmphysema and airway disease both relate to clinically important parameters. The relative influence of airway disease is greater for SGRQ; the relative influence of emphysema is greater for BODE.
Details
- Title: Subtitle
- Relationship between quantitative CT metrics and health status and BODE in chronic obstructive pulmonary disease
- Creators
- Carlos H Martinez - University of Michigan–Ann ArborYa-Hong Chen - Peking UniversityPhillip M Westgate - University of Michigan–Ann ArborLyrica X Liu - University of Michigan–Ann ArborSusan Murray - University of Michigan–Ann ArborJeffrey L Curtis - University of Michigan–Ann ArborBarry J Make - University of Colorado DenverElla A Kazerooni - University of Michigan–Ann ArborDavid A Lynch - University of Colorado DenverNathaniel Marchetti - Temple UniversityGeorge R Washko - Harvard UniversityFernando J Martinez - University of Michigan–Ann ArborMeiLan K Han - University of Michigan–Ann ArborCOPDGene Investigators
- Contributors
- Eric Hoffman (Contributor) - University of Iowa, Radiology
- Resource Type
- Journal article
- Publication Details
- Thorax, Vol.67(5), pp.399-406
- DOI
- 10.1136/thoraxjnl-2011-201185
- PMID
- 22514236
- PMCID
- PMC3719874
- ISSN
- 0040-6376
- eISSN
- 1468-3296
- Language
- English
- Date published
- 05/2012
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
- Record Identifier
- 9984318712902771
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