Journal article
Relationship between rate and extent of absorption of oral theophylline from Uniphyl brand of slow-release theophylline and resulting serum concentrations during multiple dosing
Journal of allergy and clinical immunology, Vol.80(5), pp.723-729
1987
DOI: 10.1016/0091-6749(87)90294-6
PMID: 3680816
Abstract
The relationship between a standardized assessment of rate and extent of absorption of slow-release theophylline and serum concentrations during multiple dosing was examined in eight healthy adult volunteers. Each subject received single doses of a reference theophylline solution in addition to single and multiple doses of Uniphyl, a “once-a-day” theophylline formulation, administered after an overnight fast and after a large breakfast. Extent of absorption was similar during single and multiple dosing but was significantly greater when dose was taken after breakfast; 68 ± 7% (mean ± SEM) and 61 ± 4% of administered doses were absorbed during single and multiple dosing, respectively, when breakfast was withheld, whereas 83 ± 4% and 86 ± 4% of administered doses were absorbed when single and multiple doses, respectively, followed breakfast. Observed mean serum concentrations during multiple dosing approximated values predicted from the single-dose study; mean peak serum concentrations averaged more than twice the tough for both predicted and observed values after both fasting and postprandial administration. These data demonstrate incomplete absorption of theophylline from Uniphyl with greater extent of absorption when Uniphyl is taken after food. The study also provides further documentation that characterization of rate and extent of absorption from single doses permit prediction of the mean serum concentration-time profile during multiple dosing at defined rates of theophylline elimination. This provides the potential to anticipate fluctuations in serum concentrations at clinically relevant elimination rates that deviate from the mean of samples typically used for study.
Details
- Title: Subtitle
- Relationship between rate and extent of absorption of oral theophylline from Uniphyl brand of slow-release theophylline and resulting serum concentrations during multiple dosing
- Creators
- Gary Milavetz - University of IowaLeigh M. Vaughan - University of IowaMiles M. Weinberger - University of IowaJames B. HarrisTimothy A. Mullenix - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of allergy and clinical immunology, Vol.80(5), pp.723-729
- Publisher
- Mosby, Inc
- DOI
- 10.1016/0091-6749(87)90294-6
- PMID
- 3680816
- ISSN
- 0091-6749
- eISSN
- 1097-6825
- Language
- English
- Date published
- 1987
- Academic Unit
- Pharmacy; Stead Family Department of Pediatrics; Pharmacy Practice and Science
- Record Identifier
- 9984366014702771
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