Journal article
Relationship of Genetic Variation in the Serotonin Transporter Gene (SLC6A4) and Congenital and Acquired Cardiovascular Diseases
Genetic testing and molecular biomarkers, Vol.19(3), pp.115-123
03/01/2015
DOI: 10.1089/gtmb.2014.0250
PMID: 25671637
Abstract
Recent reports have suggested an association between variation in the serotonin transporter and primary pulmonary hypertension and myocardial infarction. We set out to determine whether these associations were present in a population of patients who underwent
SLC6A4
genotyping and to explore whether genetic variation in the serotonin transporter might be also associated with other cardiovascular functional and structural abnormalities. Included were 3473 patients who were genotyped for the
SLC6A4
5HTTLPR polymorphism and a subset for rs25531 (
n
=816) and STin2 (
n
=819). An association was observed between 5HTTLPR and primary pulmonary hypertension (
p
=0.0130), anomalies of the cerebrovascular system (
p
<0.0001), and other anomalies of great veins (
p
=0.0359). The combined 5HTTLPR and rs25531 genotype was associated with tachycardia (
p
=0.0123). There was an association of the STin2 genotype with abnormal electrocardiogram (ECG) (
p
=0.0366) and abnormal cardiac study (0.0311). Overall, these results represent a step toward the understanding of the impact of
SLC6A4
variation on cardiovascular pathology.
Details
- Title: Subtitle
- Relationship of Genetic Variation in the Serotonin Transporter Gene (SLC6A4) and Congenital and Acquired Cardiovascular Diseases
- Creators
- Ann M Moyer - 1Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MinnesotaDenise L Walker - 2Medical Genome Facility, Mayo Clinic, Rochester, MinnesotaRajeswari Avula - 1Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MinnesotaMaria I Lapid - 3Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MinnesotaSimon Kung - 3Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MinnesotaSandra C Bryant - 4Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MinnesotaKelly K Edwards - 4Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MinnesotaJohn L Black - 1Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MinnesotaVictor M Karpyak - 3Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MinnesotaGen Shinozaki - 5Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IowaSheila G Jowsey-Gregoire - 3Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MinnesotaShawna L Ehlers - 3Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MinnesotaMagdalena Romanowicz - 6Elliot Health System, Behavioral Health Services, Manchester, New HampshireMark R Litzow - 7Division of Hematology, Mayo Clinic, Rochester, MinnesotaWilliam J Hogan - 7Division of Hematology, Mayo Clinic, Rochester, MinnesotaJames R Rundell - 8Department of Psychiatry, University of Minnesota, Minneapolis, MinnesotaW. Michael Hooten - 9Department of Anesthesiology, Mayo Clinic, Rochester, MinnesotaLinnea M Baudhuin - 1Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota
- Resource Type
- Journal article
- Publication Details
- Genetic testing and molecular biomarkers, Vol.19(3), pp.115-123
- Publisher
- Mary Ann Liebert, Inc
- DOI
- 10.1089/gtmb.2014.0250
- PMID
- 25671637
- ISSN
- 1945-0265
- eISSN
- 1945-0257
- Language
- English
- Date published
- 03/01/2015
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute; Anesthesia; Neurosurgery
- Record Identifier
- 9984070376602771
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