Relationship of Maternal Weight Status Before, During, and After Pregnancy with Breast Milk Hormone Concentrations

Ghazaleh Sadr Dadres; Kara M Whitaker; Jacob L Haapala; Laurie Foster; Katy D Smith; April M Teague; David R Jacobs Jr; Elyse O Kharbanda; Patricia M McGovern; Tonya C Schoenfuss; Laura J Le; Lisa Harnack; David A Fields; Ellen W Demerath

doi:10.1002/oby.22409

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Relationship of Maternal Weight Status Before, During, and After Pregnancy with Breast Milk Hormone Concentrations

Journal article

Peer reviewed

Relationship of Maternal Weight Status Before, During, and After Pregnancy with Breast Milk Hormone Concentrations

Ghazaleh Sadr Dadres, Kara M Whitaker, Jacob L Haapala, Laurie Foster, Katy D Smith, April M Teague, David R Jacobs Jr, Elyse O Kharbanda, Patricia M McGovern, Tonya C Schoenfuss, …

Obesity (Silver Spring, Md.), Vol.27(4), pp.621-628

04/2019

DOI: 10.1002/oby.22409

PMCID: PMC6432940

PMID: 30900412

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Abstract

The aim of this study was to test associations of prepregnancy BMI, gestational weight gain, oral glucose challenge test results, and postpartum weight loss as predictors of breast milk leptin, insulin, and adiponectin concentrations and whether these relationships vary over time. Milk was collected at 1 and 3 months from 135 exclusively breastfeeding women from the longitudinal Mothers and Infants Linked for Healthy Growth (MILk) study. Hormones were assayed in skimmed samples using ELISA. Mixed-effects linear regression models were employed to assess main effects and effect-by-time interactions on hormone concentrations. In adjusted models, BMI was positively associated with milk leptin (P < 0.001) and insulin (P = 0.03) and negatively associated with milk adiponectin (P = 0.02); however, the association was stronger with insulin and weaker with adiponectin at 3 months than at 1 month (time interaction P = 0.017 for insulin and P = 0.045 for adiponectin). Gestational weight gain was positively associated and postpartum weight loss was negatively associated with milk leptin (both P < 0.001), independent of BMI. Oral glucose challenge test results were not associated with these milk hormone concentrations. Maternal weight status before, during, and after pregnancy contributes to interindividual variation in human milk composition. Continuing work will assess the role of these and other milk bioactive factors in altering infant metabolic outcomes.

Breast Feeding

Pregnancy

Adiponectin - analysis

Adiponectin - metabolism

Adult

Body Weight - physiology

Female

Glucose Tolerance Test

Humans

Infant, Newborn

Insulin - analysis

Insulin - metabolism

Leptin - analysis

Leptin - metabolism

Longitudinal Studies

Male

Middle Aged

Milk, Human - chemistry

Milk, Human - metabolism

Mothers

Postpartum Period - metabolism

Young Adult

Details

Title: Subtitle: Relationship of Maternal Weight Status Before, During, and After Pregnancy with Breast Milk Hormone Concentrations
Creators: Ghazaleh Sadr Dadres - University of Minnesota
Kara M Whitaker - University of Minnesota
Jacob L Haapala - University of Minnesota
Laurie Foster - University of Minnesota
Katy D Smith - University of Oklahoma Health Sciences Center
April M Teague - University of Oklahoma Health Sciences Center
David R Jacobs Jr - University of Minnesota
Elyse O Kharbanda - HealthPartners
Patricia M McGovern - University of Minnesota
Tonya C Schoenfuss - University of Minnesota
Laura J Le - University of Minnesota
Lisa Harnack - University of Minnesota
David A Fields - University of Oklahoma Health Sciences Center
Ellen W Demerath - University of Minnesota
Resource Type: Journal article
Publication Details: Obesity (Silver Spring, Md.), Vol.27(4), pp.621-628
DOI: 10.1002/oby.22409
PMID: 30900412
PMCID: PMC6432940
NLM abbreviation: Obesity (Silver Spring)
ISSN: 1930-7381
eISSN: 1930-739X
Grant note: R18 OH003605 / NIOSH CDC HHS R01 HD080444 / NICHD NIH HHS
Language: English
Date published: 04/2019
Academic Unit: Epidemiology; Health, Sport, and Human Physiology
Record Identifier: 9984245773102771

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