Journal article
Relationship of Patellofemoral Osteoarthritis to Changes in Performance-based Physical Function Over 7 Years: The Multicenter Osteoarthritis Study
Journal of rheumatology, Vol.49(1), pp.98-103
01/2022
DOI: 10.3899/jrheum.210270
PMCID: PMC8724393
PMID: 34470797
Abstract
To determine the relationship of patellofemoral osteoarthritis (PFOA) to changes in performance-based function over 7 years.
There were 2666 participants (62.2 ± 8.0 yrs, BMI 30.6 ± 5.9 kg/m
, 60% female) from the Multicenter Osteoarthritis Study with knee radiographs at baseline who completed repeated chair stands and a 20-meter walk test (20MWT) at baseline, 2.5, 5, and 7 years. Generalized linear models assessed the relation of radiographic PFOA and radiographic PFOA with frequent knee pain to longitudinal changes in performance-based function. Analyses were adjusted for age, sex, BMI, tibiofemoral OA, and injury/surgery.
Linear models demonstrated a significant group-by-time interaction for the repeated chair stands (
= 0.04) and the 20MWT (
< 0.0001). Those with radiographic PFOA took 1.01 seconds longer on the repeated chair stands (
= 0.02) and 1.69 seconds longer on the 20MWT (
< 0.0001) at 7 years compared with baseline. When examining the relation of radiographic PFOA with frequent knee pain to performance-based function, there was a significant group-by-time interaction for repeated chair stands (
= 0.05) and the 20MWT (
< 0.0001). Those with radiographic PFOA with frequent knee pain increased their time on the repeated chair stands by 1.12 seconds (
= 0.04) and on the 20MWT by 1.91 seconds (
< 0.0001) over 7 years.
Individuals with radiographic PFOA and those with radiographic PFOA with frequent knee pain have worsening of performance-based function over time. This knowledge may present opportunities to plan for early treatment strategies for PFOA to limit functional decline over time.
Details
- Title: Subtitle
- Relationship of Patellofemoral Osteoarthritis to Changes in Performance-based Physical Function Over 7 Years: The Multicenter Osteoarthritis Study
- Creators
- Harvi F Hart - H.F. Hart, PhD, Faculty of Health Sciences and Bone and Joint Institute, Western University, London, Ontario, CanadaTuhina Neogi - T. Neogi, MD, PhD, Division of Rheumatology, Boston University School of Medicine, Boston, Massachusetts, USAMichael LaValley - M. LaValley, PhD, Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USADaniel White - D. White, PT, PhD, Department of Physical Therapy, University of Delaware, Newark, Delaware, USAYuqing Zhang - Y. Zhang, DSc, Department of Rheumatology, Massachusetts General Hospital, Boston, Massachusetts, USAMichael C Nevitt - M.C. Nevitt, PhD, MPH, Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USAJames Torner - J. Torner, PhD, Department of Epidemiology, The University of Iowa, Iowa City, Iowa, USACora E Lewis - C.E. Lewis, MD, MSPH, Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, USAJoshua J Stefanik - J.J. Stefanik, PT, PhD, Division of Rheumatology, Boston University School of Medicine, and Department of Physical Therapy, Movement, and Rehabilitation Sciences, Northeastern University, Boston, Massachusetts, USA. j.stefanik@northeastern.edu
- Resource Type
- Journal article
- Publication Details
- Journal of rheumatology, Vol.49(1), pp.98-103
- DOI
- 10.3899/jrheum.210270
- PMID
- 34470797
- PMCID
- PMC8724393
- NLM abbreviation
- J Rheumatol
- ISSN
- 0315-162X
- eISSN
- 1499-2752
- Grant note
- U01 AG018947 / NIA NIH HHS U01 AG018832 / NIA NIH HHS P30 AR072571 / NIAMS NIH HHS K24 AR070892 / NIAMS NIH HHS U01 AG019069 / NIA NIH HHS CIHR K23 AR070913 / NIAMS NIH HHS U01 AG018820 / NIA NIH HHS
- Language
- English
- Date published
- 01/2022
- Academic Unit
- Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
- Record Identifier
- 9984214717702771
Metrics
18 Record Views