Relationship of Sleep Duration With All-Cause Mortality and Cardiovascular Events: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies

Jiawei Yin; Xiaoling Jin; Zhilei Shan; Shuzhen Li; Hao Huang; Peiyun Li; Xiaobo Peng; Zhao Peng; Kaifeng Yu; Wei Bao; Wei Yang; Xiaoyi Chen; Liegang Liu

doi:10.1161/JAHA.117.005947

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Relationship of Sleep Duration With All-Cause Mortality and Cardiovascular Events: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies

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Relationship of Sleep Duration With All-Cause Mortality and Cardiovascular Events: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies

Jiawei Yin, Xiaoling Jin, Zhilei Shan, Shuzhen Li, Hao Huang, Peiyun Li, Xiaobo Peng, Zhao Peng, Kaifeng Yu, Wei Bao, …

Journal of the American Heart Association, Vol.6(9), e005947

09/09/2017

DOI: 10.1161/JAHA.117.005947

PMCID: PMC5634263

PMID: 28889101

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Abstract

Effects of extreme sleep duration on risk of mortality and cardiovascular outcomes remain controversial. We aimed to quantify the dose-response relationships of sleep duration with risk of all-cause mortality, total cardiovascular disease, coronary heart disease, and stroke. PubMed and Embase were systematically searched for prospective cohort studies published before December 1, 2016, that examined the associations between sleep duration and at least 1 of the 4 outcomes in generally healthy populations. U-shaped associations were indicated between sleep duration and risk of all outcomes, with the lowest risk observed for ≈7-hour sleep duration per day, which was varied little by sex. For all-cause mortality, when sleep duration was <7 hours per day, the pooled relative risk (RR) was 1.06 (95% CI, 1.04-1.07) per 1-hour reduction; when sleep duration was >7 hours per day, the pooled RR was 1.13 (95% CI, 1.11-1.15) per 1-hour increment. For total cardiovascular disease, the pooled RR was 1.06 (95% CI, 1.03-1.08) per 1-hour reduction and 1.12 (95% CI, 1.08-1.16) per 1-hour increment of sleep duration. For coronary heart disease, the pooled RR was 1.07 (95% CI, 1.03-1.12) per 1-hour reduction and 1.05 (95% CI, 1.00-1.10) per 1-hour increment of sleep duration. For stroke, the pooled RR was 1.05 (95% CI, 1.01-1.09) per 1-hour reduction and 1.18 (95% CI, 1.14-1.21) per 1-hour increment of sleep duration. Our findings indicate that both short and long sleep duration is associated with an increased risk of all-cause mortality and cardiovascular events.

Nonlinear Dynamics

Cardiovascular Diseases - physiopathology

Prospective Studies

Risk Assessment

Humans

Risk Factors

Linear Models

Male

Sleep Wake Disorders - diagnosis

Sleep Wake Disorders - mortality

Cause of Death

Sleep

Time Factors

Cardiovascular Diseases - mortality

Female

Sleep Wake Disorders - physiopathology

Odds Ratio

Cardiovascular Diseases - diagnosis

Details

Title: Subtitle: Relationship of Sleep Duration With All-Cause Mortality and Cardiovascular Events: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies
Creators: Jiawei Yin - MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China
Xiaoling Jin - MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China
Zhilei Shan - Departments of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA
Shuzhen Li - MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China
Hao Huang - MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China
Peiyun Li - MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China
Xiaobo Peng - MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China
Zhao Peng - MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China
Kaifeng Yu - MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China
Wei Bao - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA
Wei Yang - MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China
Xiaoyi Chen - Guangzhou Medical University
Liegang Liu - MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China
Resource Type: Journal article
Publication Details: Journal of the American Heart Association, Vol.6(9), e005947
Publisher: England
DOI: 10.1161/JAHA.117.005947
PMID: 28889101
PMCID: PMC5634263
ISSN: 2047-9980
eISSN: 2047-9980
Language: English
Date published: 09/09/2017
Academic Unit: Epidemiology; Fraternal Order of Eagles Diabetes Research Center
Record Identifier: 9983996061802771

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