Journal article
Relationship of free nortriptyline levels to therapeutic response
Acta psychiatrica Scandinavica, Vol.72(2), pp.120-125
08/1985
DOI: 10.1111/j.1600-0447.1985.tb02582.x
PMID: 4050504
Abstract
The relationship between the free plasma concentration of nortriptyline and therapeutic response was examined. Eighteen depressed inpatients were treated for 21 days with steady state total nortriptyline plasma concentrations between 50-150 ng/ml. Steady state free nortriptyline concentrations were measured. The therapeutic nortriptyline response was measured by administering the Hamilton and the Carroll Rating scales at day zero and day 21. Statistical relationships between free levels of drug and clinical response were found to be insignificant. Qualitative assessment of the data suggest that free serum levels of nortriptyline in excess of 10 ng/ml may have an inhibitory effect on clinical response.
Details
- Title: Subtitle
- Relationship of free nortriptyline levels to therapeutic response
- Creators
- P J PerryJ L BrowneB AlexanderB M PfohlF J DunnerA D ShermanM T Tsuang
- Resource Type
- Journal article
- Publication Details
- Acta psychiatrica Scandinavica, Vol.72(2), pp.120-125
- Publisher
- United States
- DOI
- 10.1111/j.1600-0447.1985.tb02582.x
- PMID
- 4050504
- ISSN
- 0001-690X
- eISSN
- 1600-0447
- Language
- English
- Date published
- 08/1985
- Academic Unit
- Pharmacy; Psychiatry
- Record Identifier
- 9984003946602771
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