Journal article
Relationship of neuropsychological and MRI measures to age of onset of schizophrenia
Acta psychiatrica Scandinavica, Vol.98(2), pp.156-164
Accepted for publication January 12, 1998
08/1998
DOI: 10.1111/j.1600-0447.1998.tb10058.x
PMID: 9718243
Abstract
Age of onset of schizophrenia (AOS) may be largely determined by neurobiological factors. We examined in a diverse sample of schizophrenia out-patients the relationships of AOS with neuropsychological abilities and structural brain abnormalities as measured on cerebral magnetic resonance imaging (MRI). A total of 82 out-patients meeting DSM-III-R criteria for schizophrenia were evaluated with a comprehensive neuropsychological battery and semi-automated quantitatively analysed cerebral MRI. Earlier AOS correlated with poorer performance in learning and abstraction/ cognitive flexibility, and with larger volumes of caudate and lenticular nuclei, and smaller volume of thalamus on MRI. A model for predicting AOS consisting of abstraction and thalamic and caudate volumes remained significant after controlling for duration of illness, current age and daily neuroleptic dose. In conclusion, AOS may be related to specific rather than general measures of cognitive performance and structural brain abnormalities.
Details
- Title: Subtitle
- Relationship of neuropsychological and MRI measures to age of onset of schizophrenia
- Creators
- D. V Jeste - Department of Psychiatry, University of California, San Diego and San Diego VA Medical Center, San Diego, CA, USAL. A McAdams - Department of Psychiatry, University of California, San Diego and San Diego VA Medical Center, San Diego, CA, USAB. W Palmer - Department of Psychiatry, University of California, San Diego and San Diego VA Medical Center, San Diego, CA, USAD Braff - Department of Psychiatry, University of California, San Diego and San Diego VA Medical Center, San Diego, CA, USAT. L Jernigan - Department of Psychiatry, University of California, San Diego and San Diego VA Medical Center, San Diego, CA, USAJ. S Paulsen - Department of Psychiatry, University of California, San Diego and San Diego VA Medical Center, San Diego, CA, USAJ. C Stout - Department of Psychiatry, University of California, San Diego and San Diego VA Medical Center, San Diego, CA, USAL. L Symonds - Department of Psychiatry, University of California, San Diego and San Diego VA Medical Center, San Diego, CA, USAA Bailey - Department of Psychiatry, University of California, San Diego and San Diego VA Medical Center, San Diego, CA, USAR. K Heaton - Department of Psychiatry, University of California, San Diego and San Diego VA Medical Center, San Diego, CA, USA
- Resource Type
- Journal article
- Publication Details
- Acta psychiatrica Scandinavica, Vol.98(2), pp.156-164
- Edition
- Accepted for publication January 12, 1998
- Publisher
- Blackwell Publishing Ltd
- DOI
- 10.1111/j.1600-0447.1998.tb10058.x
- PMID
- 9718243
- ISSN
- 0001-690X
- eISSN
- 1600-0447
- Number of pages
- 9
- Language
- English
- Date published
- 08/1998
- Academic Unit
- Psychiatry; Psychological and Brain Sciences
- Record Identifier
- 9984083845202771
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