Relationship of number of seizures recorded on video-EEG to surgical outcome in refractory medial temporal lobe epilepsy

Rup Kamal Sainju; Bethany Jacobs Wolf; Leonardo Bonilha; Gabriel Martz

doi:10.1590/S0004-282X2012000900009

$Relationship of number of seizures recorded on video-EEG to surgical outcome in refractory medial temporal lobe epilepsy$

Journal article

Open access

Peer reviewed

Relationship of number of seizures recorded on video-EEG to surgical outcome in refractory medial temporal lobe epilepsy

Rup Kamal Sainju, Bethany Jacobs Wolf, Leonardo Bonilha and Gabriel Martz

Arquivos de neuro-psiquiatria, Vol.70(9), pp.694-699

09/2012

DOI: 10.1590/S0004-282X2012000900009

PMCID: PMC4207424

PMID: 22990726

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Abstract

Surgical planning for refractory medial temporal lobe epilepsy (rMTLE) relies on seizure localization by ictal electroencephalography (EEG). Multiple factors impact the number of seizures recorded. We evaluated whether seizure freedom correlated to the number of seizures recorded, and the related factors. We collected data for 32 patients with rMTLE who underwent anterior temporal lobectomy. Primary analysis evaluated number of seizures captured as a predictor of surgical outcome. Subsequent analyses explored factors that may seizure number. Number of seizures recorded did not predict seizure freedom. More seizures were recorded with more days of seizure occurrence (p<0.001), seizure clusters (p≤0.011) and poorly localized seizures (PLSz) (p=0.004). Regression modeling showed a trend for subjects with fewer recorded poorly localized seizures to have better surgical outcome (p=0.052). Total number of recorded seizures does not predict surgical outcome. Patients with more PLSz may have worse outcome.

Humans

Middle Aged

Logistic Models

Male

Seizures - diagnosis

Treatment Outcome

Epilepsy, Temporal Lobe - surgery

Electroencephalography - methods

Young Adult

Magnetic Resonance Imaging

Video Recording

Adult

Female

Aged

Retrospective Studies

Details

Title: Subtitle: Relationship of number of seizures recorded on video-EEG to surgical outcome in refractory medial temporal lobe epilepsy
Creators: Rup Kamal Sainju - Division of Neurology, Department of Neurosciences, Medical University of South Carolina (MUSC), Charleston, SC 29425, USA. dr.sainju@gmail.com
Bethany Jacobs Wolf
Leonardo Bonilha
Gabriel Martz
Resource Type: Journal article
Publication Details: Arquivos de neuro-psiquiatria, Vol.70(9), pp.694-699
DOI: 10.1590/S0004-282X2012000900009
PMID: 22990726
PMCID: PMC4207424
NLM abbreviation: Arq Neuropsiquiatr
ISSN: 0004-282X
eISSN: 1678-4227
Publisher: Brazil
Grant note: UL1 TR000062 / NCATS NIH HHS UL1RR029882 / NCRR NIH HHS UL1 RR029882 / NCRR NIH HHS
Language: English
Date published: 09/2012
Academic Unit: Neurology
Record Identifier: 9984020624502771

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