Journal article
Relationship of opioid tolerance to patient and wound factors, and wound micro-environment in patients with open wounds
Journal of wound care, Vol.34(Sup2), pp.S6-S16
02/01/2025
DOI: 10.12968/jowc.2023.0215
PMID: 39928508
Abstract
Objective:
Opioid tolerance is a criterion for opioid use disorder, which is currently an epidemic in the US. Individuals with open wounds are frequently administered opioids; however, the phenomenon of opioid tolerance has not been examined in the context of wounds. The purpose of this exploratory study was to compare patient/wound factors, wound microbiome and inflammatory mediators between individuals who were opioid-tolerant versus those who were not opioid-tolerant.
Method:
Patients with acute open wounds were enrolled in this cross-sectional study. All study data were collected before and during a one-time study dressing change.
Results:
The study included a total of 385 participants. Opioid-tolerant participants were significantly younger (p<0.0001); had higher levels of depression (p=0.0055) and anxiety (p=0.0118); had higher pain catastrophising scores (p=0.0035); reported higher resting wound pain (p<0.0001); had a higher number of wounds of <30 days' duration (p=0.0486); and had wounds with lower bacterial richness (p=0.0152) than participants who were not opioid-tolerant. A backward elimination logistic regression model showed that four predictors—resting wound pain, age, bacterial richness and depression—were the most important variables in predicting opioid-tolerance status.
Conclusion:
These findings provide the first insights into the phenomenon of opioid tolerance in the context of open wounds. This study provides findings from which to guide hypothesis-driven research in the future.
Details
- Title: Subtitle
- Relationship of opioid tolerance to patient and wound factors, and wound micro-environment in patients with open wounds
- Creators
- Jaewon Bae - University of IowaAmy Campbell - University of PennsylvaniaMaria Hein - University of IowaStephen L Hillis - University of IowaElizabeth Grice - University of PennsylvaniaBarbara A Rakel - University of IowaSue E Gardner - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of wound care, Vol.34(Sup2), pp.S6-S16
- Publisher
- MA Healthcare
- DOI
- 10.12968/jowc.2023.0215
- PMID
- 39928508
- ISSN
- 0969-0700
- eISSN
- 2052-2916
- Grant note
- National Institutes of Health: R01NR015642 Center for Advancing Translational Sciences: UL1TR002537
Declaration of interest: This work was supported by the National Institutes of Health (grant number: R01NR015642) , US, and Center for Advancing Translational Sciences (grant number: UL1TR002537) , US. The authors have no conflicts of interest.
- Language
- English
- Date published
- 02/01/2025
- Academic Unit
- Radiology; Biostatistics; Nursing
- Record Identifier
- 9984791075802771
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