Relationship of patent ductus arteriosus management with neonatal AKI

Ronnie Guillet; David T Selewski; Russell Griffin; Shantanu Rastogi; David J Askenazi; Carl T D'Angio; Neonatal Kidney Collaborative

doi:10.1038/s41372-021-01054-1

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Relationship of patent ductus arteriosus management with neonatal AKI

Journal article

Open access

Peer reviewed

Relationship of patent ductus arteriosus management with neonatal AKI

Ronnie Guillet, David T Selewski, Russell Griffin, Shantanu Rastogi, David J Askenazi, Carl T D'Angio and Neonatal Kidney Collaborative

Journal of perinatology, Vol.41(6), pp.1441-1447

06/2021

DOI: 10.1038/s41372-021-01054-1

PMCID: PMC8238821

PMID: 33875795

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https://www.ncbi.nlm.nih.gov/pmc/articles/8238821View

Open Access

Abstract

Investigate relationship between management of patent ductus arteriosus (PDA) and acute kidney injury (AKI) in very low birthweight neonates. Retrospective cohort study of neonates, <1500 g, admitted to 24 NICUs, 1/1/14 - 3/31/14. AKI diagnosed using the neonatal modified KDIGO definition; diagnosis and treatment of PDA extracted from the medical record. Demographics, clinical characteristics, and AKI stage compared using chi-square and analysis of variance. A general estimating equation logistic regression used to estimate adjusted odds ratios. Of 526 neonates with sufficient data to diagnose AKI, 157 (30%) had PDA (61 conservative management, 62 pharmacologic treatment only, 34 surgical ligation). In analyses adjusted for sex, birthweight, gestational age, caffeine, nephrotoxin exposure, vasopressor and mechanical ventilation use, with conservative management as reference, there were no differences among treatment cohorts in the odds of AKI. The underlying physiology of PDA, not management strategy, may determine the likelihood of AKI in neonates <1500 g.

Acute Kidney Injury - diagnosis

Acute Kidney Injury - etiology

Acute Kidney Injury - therapy

Ductus Arteriosus, Patent - complications

Ductus Arteriosus, Patent - therapy

Humans

Retrospective Studies

Details

Title: Subtitle: Relationship of patent ductus arteriosus management with neonatal AKI
Creators: Ronnie Guillet - Golisano Children's Hospital
David T Selewski - Medical University of South Carolina
Russell Griffin - University of Alabama at Birmingham
Shantanu Rastogi - Children's National
David J Askenazi - University of Alabama at Birmingham
Carl T D'Angio - Golisano Children's Hospital
Neonatal Kidney Collaborative
Contributors: Tarah T Colaizy (Contributor) - University of Iowa, Neonatology
Jonathan M Klein (Contributor) - University of Iowa, Neonatology
Resource Type: Journal article
Publication Details: Journal of perinatology, Vol.41(6), pp.1441-1447
DOI: 10.1038/s41372-021-01054-1
PMID: 33875795
PMCID: PMC8238821
NLM abbreviation: J Perinatol
ISSN: 0743-8346
eISSN: 1476-5543
Grant note: UL1 TR001417 / NCATS NIH HHS U54 TR001356 / NCATS NIH HHS UL1 TR001449 / NCATS NIH HHS UL1 TR003096 / NCATS NIH HHS
Language: English
Date published: 06/2021
Academic Unit: Stead Family Department of Pediatrics; Neonatology
Record Identifier: 9984354120602771

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