Relationship of perfusion to edema in the 9L gliosarcoma

R. G STEEN; S KROMHOUT-SCHIRO; M. M GRAHAM

doi:10.1007/BF01324839

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Relationship of perfusion to edema in the 9L gliosarcoma

Journal article

Peer reviewed

Relationship of perfusion to edema in the 9L gliosarcoma

R. G STEEN, S KROMHOUT-SCHIRO and M. M GRAHAM

Journal of neuro-oncology, Vol.16(1), pp.81-87

1993

DOI: 10.1007/BF01324839

PMID: 8410147

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Abstract

The relationship between tumor perfusion and edema was analyzed, with edema characterized as tumor wet/dry weight ratio. Perfusion of subcutaneous 9L gliosarcoma was measured by injection of 133Xe in saline into the tumor core, followed by gamma camera imaging of 133Xe washout kinetics. A significant inverse correlation was found between edema and tumor perfusion (p < 0.0002), suggesting that edema can limit tumor perfusion, perhaps through a mechanism of increased interstitial fluid pressure. The perfusion rate of highly edematous tumors was reduced to less than 10% of the perfusion rate of less edematous tumors (p < 0.001). It was also found that tumor edema increased significantly with increasing tumor volume (p < 0.001), which could account for the finding that perfusion declined significantly with increasing tumor volume (p < 0.02). These findings are potentially important because it is possible to quantify tumor edema in vivo, with millimeter resolution, using 1H magnetic resonance imaging (MRI). Thus MRI may provide a non-invasive technique for characterizing tumor perfusion or tumor drug delivery.

Neurology

Biological and medical sciences

Medical sciences

Nervous system involvement in other diseases. Miscellaneous

Details

Title: Subtitle: Relationship of perfusion to edema in the 9L gliosarcoma
Creators: R. G STEEN - Univ. Washington school medicine, dep. radiology, Seattle WA 98195, United States
S KROMHOUT-SCHIRO - Univ. Washington school medicine, dep. radiology, Seattle WA 98195, United States
M. M GRAHAM - Univ. Washington school medicine, dep. radiology, Seattle WA 98195, United States
Resource Type: Journal article
Publication Details: Journal of neuro-oncology, Vol.16(1), pp.81-87
Publisher: Springer; Dordrecht
DOI: 10.1007/BF01324839
PMID: 8410147
ISSN: 0167-594X
eISSN: 1573-7373
Language: English
Date published: 1993
Academic Unit: Radiology; Radiation Oncology
Record Identifier: 9984047750802771

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